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C-Reactive Protein: An Important Inflammatory Marker of Coronary Atherosclerotic Disease

Xiaona Zhao1,2, Cheng Gao2, Hongfang Chen3

  • 1Guangxi University of Chinese Medicine, Nanning, China.

Angiology
|August 10, 2024
PubMed

Insights

C-reactive protein (CRP) is a key inflammatory biomarker that significantly elevates cardiovascular disease (CVD) risk. Research confirms CRP

Area of Science:

  • Cardiovascular Medicine
  • Inflammation Biology
  • Biomarker Research

Background:

  • Cardiovascular disease (CVD) is a leading global cause of mortality.
  • Coronary atherosclerotic heart disease (CHD) drives most CVD events.
  • Inflammation is a critical factor in the pathogenesis of CHD.

Purpose of the Study:

  • To review the association between C-reactive protein (CRP) and cardiovascular disease (CVD).
  • To explore CRP's role in atherosclerosis (AS) and CHD development.
  • To highlight CRP's clinical utility in risk stratification and prognosis.

Main Methods:

  • Extensive literature search on PubMed.
  • Inclusion of review and research articles from January 2000 to April 2024.
  • Synthesis of evidence linking CRP to inflammation, AS, and CHD.

Main Results:

  • CRP is consistently identified as a risk enhancer for CVD.
  • CRP aids in refining risk stratification and identifying at-risk individuals.
  • CRP levels correlate with disease progression and predict recurrent cardiovascular events.

Conclusions:

  • CRP is a valuable biomarker in understanding and managing cardiovascular disease.
  • CRP's involvement in AS pathogenesis offers potential for targeted therapies.
  • CRP has significant clinical applications for risk assessment and patient management.

Keywords:
C-reactive proteinatherosclerosiscoronary heart diseaseinflammationprevention and treatment

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