Related Experiment Video

Updated: May 5, 2026

Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy
10:22

Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy

Published on: December 6, 2016

20.3K

Epilepsy after acute central nervous system complications of pediatric hematopoietic cell transplantation: A

Luca Bergonzini1, Davide Leardini2, Roberta Rao3

  • 1IRCCS Istituto delle Scienze Neurologiche di Bologna, U.O.C. Neuropsichiatria dell'età pediatrica, Member of the ERN EpiCare, Bologna, , Italy; Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum - University of Bologna, Bologna, Italy.

Seizure
|August 10, 2024
PubMed

Insights

Pediatric patients with central nervous system (CNS) complications after haematopoietic cell transplantation (HCT) have a higher risk of developing long-term epilepsy. Acute symptomatic status epilepticus (SE) during HCT significantly increases this risk, warranting specific neurological follow-up.

Area of Science:

  • Neurology
  • Pediatric Hematology/Oncology
  • Transplantation Medicine

Background:

  • Acute central nervous system (CNS) complications are frequent in pediatric hematopoietic cell transplantation (HCT) patients.
  • Long-term outcomes of these CNS complications, particularly epilepsy, remain largely unknown.
  • This study investigates the incidence, characteristics, and risk factors for long-term epilepsy following acute CNS complications in pediatric HCT.

Purpose of the Study:

  • To determine the incidence and characteristics of long-term epilepsy in pediatric HCT survivors with prior acute CNS complications.
  • To identify risk factors associated with the development of epilepsy.
  • To inform potential follow-up strategies for this vulnerable patient population.

Main Methods:

  • Retrospective analysis of pediatric patients undergoing autologous or allogeneic HCT between 2000 and 2022.
  • Inclusion criteria: development of acute CNS complications post-HCT.
  • Epilepsy diagnosis based on unprovoked seizures during follow-up; data on clinical, therapeutic, and prognostic factors were analyzed.

Main Results:

  • Ninety-four pediatric patients were included (median age 10 years).
  • Most common CNS complications were posterior reversible encephalopathy syndrome (46%) and infections (16%).
  • 9.6% of patients developed long-term focal epilepsy (5-year cumulative incidence 13.3%); acute symptomatic status epilepticus (SE) was a significant risk factor (OR=14).

Conclusions:

  • Pediatric HCT patients with CNS complications exhibit a higher epilepsy occurrence compared to the general population.
  • Acute symptomatic SE during HCT is strongly associated with an increased risk of developing long-term epilepsy.
  • These findings support the need for targeted neurological surveillance in pediatric HCT survivors with CNS complications.
Abstract

Keywords:
ComplicationsEpilepsyHematopoietic cell transplantationSeizuresStatus epilepticus

More Related Videos

Use of a Wireless Video-EEG System to Monitor Epileptiform Discharges Following Lateral Fluid-Percussion Induced Traumatic Brain Injury09:16

Use of a Wireless Video-EEG System to Monitor Epileptiform Discharges Following Lateral Fluid-Percussion Induced Traumatic Brain Injury

Published on: June 21, 2019

25.6K
Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization09:57

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization

Published on: September 20, 2024

2.6K

Related Concept Videos

Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
1.8K
Seizures: Classification01:13

Seizures: Classification

Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
2.5K
Encephalitis l: Introduction01:19

Encephalitis l: Introduction

Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
27
Epilepsy ll: Types01:22

Epilepsy ll: Types

Recurrent seizures, stemming from abnormal electrical activity in the brain, are the defining characteristic of epilepsy, a chronic neurological condition. Because seizure features vary greatly, epilepsy is classified using two systems: by seizure type and by epilepsy syndromes. These classifications enable clinicians to describe seizure patterns and select suitable treatment strategies.I. Classification by Seizure Type1. Focal EpilepsyFocal epilepsy begins in one hemisphere of the brain.
54