Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Acid Suppressive Drugs for Peptic Ulcer Disease: Proton Pump Inhibitors01:13

Acid Suppressive Drugs for Peptic Ulcer Disease: Proton Pump Inhibitors

363
Peptic ulcers, often induced by H. pylori infections or NSAID usage, arise from disruptions in the delicate balance of gastric acid production. Peptic ulcers stem from heightened gastric acid levels due to H. pylori infections or NSAID use. The protective mucus layer diminishes in the presence of these factors, allowing gastric acid to erode the stomach lining and form ulcers.
Gastric acid, a potent cocktail of hydrogen and chloride ions, is produced in specialized parietal cells within the...
363
Acid Suppressive Drugs for Peptic Ulcer Disease: Histamine H2-Receptor Antagonists01:28

Acid Suppressive Drugs for Peptic Ulcer Disease: Histamine H2-Receptor Antagonists

412
Histamine H2 receptors, which are intricately located on the basolateral membrane of parietal cells, play a crucial role in modulating gastric acid secretion. When released from enterochromaffin-like cells, histamine engages H2 receptors, initiating the cyclic AMP (cAMP) pathway. In this pathway, adenylyl cyclase converts ATP into cAMP, elevating intracellular cAMP levels. The activation of protein kinase A follows, stimulating the proton pump. This stimulation prompts the secretion of hydrogen...
412
Acid Suppressive Drugs for Peptic Ulcer Disease: Antacids01:31

Acid Suppressive Drugs for Peptic Ulcer Disease: Antacids

337
In the complex environment of the gastric lumen, excessive acid secretion can lead to the formation or worsening of ulcers within the delicate mucosal layer. Antacids, such as sodium bicarbonate and calcium carbonate, provide relief by neutralizing this acid, transforming it into harmless salt and water. This neutralization process raises the gastric pH from a highly acidic level of 1 to a more basic 3-4, reducing the acidity within the stomach.
However, this neutralization reaction between...
337
What is Monogastric Digestion?01:50

What is Monogastric Digestion?

70.9K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
70.9K
Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors01:24

Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors

362
Peptic ulcer disease, commonly called PUD, represents a multifaceted condition characterized by disruptions in the lining of the gastrointestinal (GI)  tract. Central to the protection of the gastrointestinal lining is the mucosal-bicarbonate barrier. This physiological defense mechanism is a formidable shield against the corrosive effects of gastric acid and pepsin secretion in the stomach. Its role is pivotal in maintaining the structural integrity of the stomach's inner lining.
362
Peptic Ulcer Disease IV: Management01:26

Peptic Ulcer Disease IV: Management

79
Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
79
  1. Home
  3. Research Domains
  5. Agricultural, Veterinary And Food Sciences
  7. Veterinary Sciences
  9. Veterinary Medicine (excl. Urology)
  11. Ph-independent Effects Of Acid Suppressants In Dogs And Cats: A One Health Perspective And Case For Further Investigation

pH-independent effects of acid suppressants in dogs and cats: a One Health perspective and case for further investigation

Emily N Gould1, Kylie Grady2, M Katherine Tolbert1

  • 1Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX.

American Journal of Veterinary Research
|August 10, 2024

Related Experiment Videos

Therapeutic Effectiveness of a Dietary Supplement for Management of Halitosis in Dogs
07:33

Therapeutic Effectiveness of a Dietary Supplement for Management of Halitosis in Dogs

Published on: July 6, 2015

11.4K
Behavioral Disturbances: An Innovative Approach to Monitor the Modulatory Effects of a Nutraceutical Diet
07:05

Behavioral Disturbances: An Innovative Approach to Monitor the Modulatory Effects of a Nutraceutical Diet

Published on: January 3, 2017

8.9K
A Model of Self-limited Acute Lung Injury by Unilateral Intra-bronchial Acid Instillation
00:07

A Model of Self-limited Acute Lung Injury by Unilateral Intra-bronchial Acid Instillation

Published on: August 30, 2019

9.0K

View abstract on PubMed

Summary
This summary is machine-generated.

Acid-suppressant drugs (ASDs) offer benefits beyond acid reduction, impacting inflammation, immunity, and cell growth. Further veterinary research is needed to explore these pH-independent effects in companion animals.

Area of Science:

  • Veterinary Pharmacology
  • One Health
  • Drug Mechanisms

Background:

  • Acid-suppressant drugs (ASDs) are primarily used for acid-related disorders in companion animals.
  • Current knowledge focuses on ASDs' efficacy in treating gastroesophageal reflux and gastrointestinal ulceration.
  • Limited understanding exists regarding ASDs' effects beyond parietal cells, including impacts on inflammation, immunomodulation, tumorigenesis, fibrosis, and oxidative stress.

Purpose of the Study:

  • To review the pH-independent properties of ASDs.
  • To raise awareness of these non-acid-related effects.
  • To highlight the need for expanded veterinary research into ASDs' broader biological impacts.

Main Methods:

  • Literature review of studies primarily from human and rodent models.
Keywords:
esomeprazolefamotidinehistamine-2 receptor antagonistomeprazole

Related Experiment Videos

Therapeutic Effectiveness of a Dietary Supplement for Management of Halitosis in Dogs
07:33

Therapeutic Effectiveness of a Dietary Supplement for Management of Halitosis in Dogs

Published on: July 6, 2015

11.4K
Behavioral Disturbances: An Innovative Approach to Monitor the Modulatory Effects of a Nutraceutical Diet
07:05

Behavioral Disturbances: An Innovative Approach to Monitor the Modulatory Effects of a Nutraceutical Diet

Published on: January 3, 2017

8.9K
A Model of Self-limited Acute Lung Injury by Unilateral Intra-bronchial Acid Instillation
00:07

A Model of Self-limited Acute Lung Injury by Unilateral Intra-bronchial Acid Instillation

Published on: August 30, 2019

9.0K
  • Focus on research demonstrating pH-independent actions of ASDs.
  • Synthesis of findings related to inflammation, immunomodulation, tumorigenesis, fibrosis, and oxidative stress.

    • Main Results:

    • ASDs exhibit effects independent of gastric pH modulation.
    • Evidence suggests ASDs can influence inflammatory and immune responses.
    • Studies indicate potential roles in processes like tumorigenesis, fibrosis, and oxidative stress.

    Conclusions:

    • ASDs possess significant pH-independent properties.
    • These properties warrant further investigation in veterinary medicine.
    • Expanded research is crucial to fully understand ASDs' benefits and risks in companion animals.
    proton pump inhibitor