Related Experiment Video

Updated: Oct 21, 2026

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291
06:51

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291

Published on: December 10, 2016

[Multicenter trials of a new cephalosporin (ceftriaxone) in childhood]

F De Francesco, R Ciliberto, G Calcagno

    La Pediatria Medica E Chirurgica : Medical and Surgical Pediatrics
    |March 1, 1985
    PubMed

    Insights

    Ceftriaxone, a new drug, effectively treated respiratory infections in 40 children. Administered once daily, it showed no adverse tissue effects, making it a safe and convenient option.

    Area of Science:

    • Pediatrics
    • Infectious Diseases
    • Pharmacology

    Background:

    • Respiratory tract infections are common in children.
    • Effective and safe antibiotic options are crucial for pediatric care.

    Purpose of the Study:

    • To evaluate the efficacy and safety of Ceftriaxone in treating pediatric respiratory tract infections.

    Main Methods:

    • A study involving 40 children with upper and lower respiratory tract infections.
    • Administration of Ceftriaxone once daily.

    Main Results:

    • Ceftriaxone demonstrated remarkable effectiveness in treating the infections.
    • The drug was easy to administer, requiring only a single daily dose.
    • No instances of tissue or parenchymal involvement were reported as side effects.

    Conclusions:

    • Ceftriaxone is a highly effective and safe antibiotic for pediatric respiratory tract infections.
    • Its once-daily dosing regimen enhances usability and patient compliance.

    More Related Videos

    Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations11:15

    Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations

    Published on: July 24, 2021

    Clinical Efficacy of an Innovative Multidimensional Traction Therapy in Moderate Adolescent Idiopathic Scoliosis07:12

    Clinical Efficacy of an Innovative Multidimensional Traction Therapy in Moderate Adolescent Idiopathic Scoliosis

    Published on: February 10, 2026

    Related Concept Videos

    Drug Dosing: Infants and Children01:29

    Drug Dosing: Infants and Children

    Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
    Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

    Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

    Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
    Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

    Pharmacokinetics in Pediatric Patients: Drug Distribution

    Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight, compared...
    Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

    Pharmacokinetics in Pediatric Patients: Drug Excretion

    In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...