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Acute urticaria and cardiovascular diseases
Eli Magen1, Eugene Merzon2, Ilan Green3
1Leumit Health Services, Tel Aviv-Yafo 6473817, Israel; Medicine A Department, Assuta Ashdod University Hospital Faculty of Health Sciences, Ben-Gurion University, 8410501, Beer-Sheba, Israel.
The American Journal of the Medical Sciences
|August 10, 2024
Summary
Acute urticaria (AU) patients have significantly higher rates of cardiovascular comorbidities, including heart disease and hypertension. This highlights the need to consider cardiovascular health in AU management and research.
Area of Science:
- Dermatology
- Cardiology
- Epidemiology
Background:
- Acute urticaria (AU) is a common skin condition with various triggers.
- Cardiovascular comorbidities in chronic urticaria are known, but less is understood about AU.
Purpose of the Study:
- To identify and assess the clinical significance of cardiovascular comorbidities in patients with acute urticaria.
Main Methods:
- Retrospective cohort study utilizing data from Leumit Health Services.
- Matched AU patients with a control group for comparison.
- Analyzed demographic, clinical, and laboratory data using statistical tests.
Main Results:
- AU patients (n=72,851) showed elevated blood pressure, BMI, glucose, and inflammatory markers compared to controls (n=291,404).
- Significant associations found between AU and valvular heart diseases, arrhythmias, deep vein thrombosis, peripheral artery disease, cerebrovascular disease, coronary artery disease, and inflammatory heart diseases.
- Increased prevalence of antihistamine and glucocorticoid use in the AU group.
Conclusions:
- Cardiovascular comorbidities are prevalent in AU patients, necessitating their consideration in clinical management.
- The findings suggest potential shared underlying mechanisms between AU and cardiovascular diseases.
- Further research is required to validate and explore these associations.
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