Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Role of Cerebellum and Prefrontal Cortex in Memory

Role of Cerebellum and Prefrontal Cortex in Memory

The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Robust variability of grid cell properties within individual grid modules enhances encoding of local space.

eLife·2025

Same author

The estrous cycle modulates hippocampal spine dynamics, dendritic processing, and spatial coding.

bioRxiv : the preprint server for biology·2024

Same author

Robust variability of grid cell properties within individual grid modules enhances encoding of local space.

bioRxiv : the preprint server for biology·2024

Same author

Coregistration of heading to visual cues in retrosplenial cortex.

Nature communications·2023

Same author

Long-term transverse imaging of the hippocampus with glass microperiscopes.

eLife·2022

Same author

Retinoic acid inhibitors mitigate vision loss in a mouse model of retinal degeneration.

Science advances·2022

Same journal

Kat5 deficiency in alveolar type II cells licenses STAT6-driven glycolytic reprogramming and pulmonary fibrosis.

Nature communications·2026

Same journal

Continuous nonthermal slab gap formed by progressive tearing beneath Northeast Asia.

Nature communications·2026

Same journal

Zeolitic isolated protonic acid sites-mediated NH<sub>3</sub> storage for robust NO<sub>x</sub> removal.

Nature communications·2026

Same journal

Coaxially nested component with asymmetric fiber resonant cavity and separation membrane for gaseous and dissolved gases detection.

Nature communications·2026

Same journal

Near-unity charge readout signal in a nonlinear resonator without matching the sensor dissipation.

Nature communications·2026

Same journal

Prokaryotic Schlafen proteins cleave tRNAs during type III CRISPR immunity.

Nature communications·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 17, 2025

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication

Published on: February 6, 2019

Differential stability of task variable representations in retrosplenial cortex.

Luis M Franco^1,2, Michael J Goard^3,4,5

¹Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, CA, USA. luisfran@uoregon.edu.

Nature Communications

|August 10, 2024

Summary

This summary is machine-generated.

Neurons in the mouse retrosplenial cortex (RSC) store information with varying stability. Context and outcome representations are more stable than motor choices, balancing reliability and flexibility in association areas.

More Related Videos

Automated Visual Cognitive Tasks for Recording Neural Activity Using a Floor Projection Maze

Automated Visual Cognitive Tasks for Recording Neural Activity Using a Floor Projection Maze

Published on: February 20, 2014

Performing Behavioral Tasks in Subjects with Intracranial Electrodes

Performing Behavioral Tasks in Subjects with Intracranial Electrodes

Published on: October 2, 2014

Related Experiment Videos

Last Updated: Jun 17, 2025

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication

Published on: February 6, 2019

Automated Visual Cognitive Tasks for Recording Neural Activity Using a Floor Projection Maze

Automated Visual Cognitive Tasks for Recording Neural Activity Using a Floor Projection Maze

Published on: February 20, 2014

Performing Behavioral Tasks in Subjects with Intracranial Electrodes

Performing Behavioral Tasks in Subjects with Intracranial Electrodes

Published on: October 2, 2014

Area of Science:

Neuroscience
Cognitive Neuroscience
Systems Neuroscience

Background:

Cortical neurons encode information over diverse timescales.
Association areas multiplex behaviorally relevant variables.
Information stability within brain regions is not fully understood.

Purpose of the Study:

To investigate the stability of neuronal representations in the mouse retrosplenial cortex (RSC).
To quantify the stability of context, trial outcome, and motor choice representations.
To understand how information stability varies within an association area.

Main Methods:

Longitudinal recording of neuronal population activity in mice.
Performance of a context-choice association task.
Linear classification to quantify representational stability.

Main Results:

Neuronal activity in the RSC exhibits varying stability across days.
Representations of context and trial outcome are more stable than motor choice.
Stability differences were observed at both single-cell and population levels.

Conclusions:

The retrosplenial cortex (RSC) stores information with differential stability.
This varying stability balances representational reliability and flexibility.
Findings highlight a key characteristic of association areas in information processing.