Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Functional inactivation of oligosaccharyltransferase a isoform suppresses tumor metastasis.

Glycobiology·2026
Same author

Metabolic clogging of mannose triggers dNTP loss and genomic instability in human cancer cells.

eLife·2023
Same author

Glycan quality control in and out of the endoplasmic reticulum of mammalian cells.

The FEBS journal·2021
Same journal

The effects of two Leu-to-Pro substitutions, L57P and L43P, on structural and functional properties of cardiac tropomyosin.

The FEBS journal·2026
Same journal

Stimulating proteasomal degradation in human proteinopathies.

The FEBS journal·2026
Same journal

A lipid-sensitive food choice behavior influences aging outcomes from a longevity-promoting diet.

The FEBS journal·2026
Same journal

The interaction network of a rice seed-specific transcription factor OsMADS29 and the calcium sensors, calmodulin, and calmodulin-like proteins.

The FEBS journal·2026
Same journal

A large family of unusual voltage-sensing proton channels (Hv3) in mollusks.

The FEBS journal·2026
Same journal

RVB-1 and RVB-2 are stress responsive proteins in Neurospora crassa and RVB-1 interacts with the centromeric Shugoshin (SGO-1) protein.

The FEBS journal·2026
See all related articles

Related Experiment Video

Updated: Jun 12, 2026

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
14:20

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

Manipulating mannose metabolism as a potential anticancer strategy.

Yoichiro Harada1

  • 1Department of Glyco-Oncology and Medical Biochemistry, Research Institute, Osaka International Cancer Institute, Japan.

The FEBS Journal
|August 11, 2024
PubMed
Summary
This summary is machine-generated.

Mannose can slow cancer cell growth and increase chemotherapy effectiveness by disrupting the Warburg effect. Targeting mannose metabolism offers a promising new strategy for cancer treatment.

Keywords:
Warburg effectcancerchemotherapyglucoseglycolysisglycosylationmannosemetabolismtumor

More Related Videos

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo
08:19

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo

Published on: July 20, 2019

Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases
09:48

Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases

Published on: August 23, 2024

Related Experiment Videos

Last Updated: Jun 12, 2026

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
14:20

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo
08:19

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo

Published on: July 20, 2019

Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases
09:48

Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases

Published on: August 23, 2024

Area of Science:

  • Biochemistry
  • Cancer Biology
  • Metabolic Pathways

Background:

  • Cancer cells exhibit altered metabolism, notably the Warburg effect, for proliferation and survival.
  • The Warburg effect involves reprogrammed glycolysis, favoring ATP generation and macromolecule synthesis.
  • Mannose, a glucose epimer, can counteract the Warburg effect, leading to chemosensitive cancer cells.

Purpose of the Study:

  • To review current knowledge on mannose metabolism in cancer.
  • To explore the potential of manipulating mannose metabolism as an anticancer strategy.
  • To understand the mechanisms linking mannose metabolism alterations to cancer cell vulnerability.

Main Methods:

  • Literature review of studies on cancer cell metabolism and mannose.
  • Analysis of the biochemical pathways involved in mannose catabolism and synthesis.
  • Examination of the impact of mannose on cancer cell proliferation and chemosensitivity.

Main Results:

  • Mannose dampens the Warburg effect, inducing slow-cycling and chemotherapy-susceptible cancer cells.
  • Compromised mannose catabolism in cancer cells is crucial for this anticancer effect.
  • De novo mannose synthesis in cancer cells presents a target for enhancing chemosensitivity via glycosylation pathways.

Conclusions:

  • Alterations in mannose metabolism can induce cancer cell vulnerability.
  • Targeting mannose metabolism, including its synthesis and catabolism, is a potential anticancer strategy.
  • Further research into the mechanisms of mannose metabolism is needed to optimize its therapeutic application.