Related Experiment Video
Updated: Jun 17, 2025
10:32
In Vitro Recording of Mesenteric Afferent Nerve Activity in Mouse Jejunal and Colonic Segments
Published on: October 25, 2016
11.5K
Renal interoception in health and disease
Louise C Evans1, Brianna Dailey-Krempel2, Mariana R Lauar1
1Department of Surgery, University of Minnesota Medical School, Minneapolis 55455, United States of America.
Autonomic Neuroscience : Basic & Clinical
|August 11, 2024
Summary
Catheter-based renal denervation, now FDA-approved for hypertension, may work by targeting sensory nerves. This approach reduces sympathetic nervous system activity, impacting blood pressure regulation beyond the kidneys.
Area of Science:
- Nephrology
- Cardiovascular Physiology
- Neuroscience
Background:
- Catheter-based renal denervation is FDA-approved for hypertension treatment.
- Its anti-hypertensive effects were traditionally linked to efferent sympathetic nerve ablation.
- Emerging research highlights the role of afferent sensory renal nerves in blood pressure regulation.
Purpose of the Study:
- To review the role of afferent renal nerves in regulating renal function and pathophysiologies.
- To describe central projections of afferent renal nerves for context on ablation/activation responses.
- To discuss the kidney's emerging role as an interoceptive organ.
Main Methods:
- Literature review focusing on afferent renal nerve function.
- Analysis of central nervous system projections of renal nerves.
- Discussion of the kidney's role in interoception and related pathologies.
Main Results:
- Afferent renal denervation is linked to reduced sympathetic nervous system activity.
- This suggests non-renal effects contributing to hypertension treatment.
- The kidney's role as an interoceptive organ is increasingly recognized.
Conclusions:
- Afferent renal nerves play a significant role in blood pressure regulation.
- Renal denervation's benefits may extend beyond direct renal effects.
- Understanding renal interoception is crucial for future hypertension therapies.
Related Concept Videos
01:29Assessment of the Gastrointestinal System II: Health Perception Pattern
87
Assessing the gastrointestinal (GI) system is a complex process that begins with collecting subjective data. This data, collected through patient interviews, provides crucial insights into the patient's health history, perception patterns, and lifestyle habits, all contributing significantly to GI health.
Health Perception Patterns
Health perception patterns offer valuable insights into a patient's lifestyle habits and how they may impact their GI health. These patterns include:
Health Perception Patterns
Health perception patterns offer valuable insights into a patient's lifestyle habits and how they may impact their GI health. These patterns include:
87
01:18Neural Regulation of Blood Pressure
2.7K
The neural regulation of blood pressure involves intricate interactions between the autonomic nervous system (ANS) and cardiovascular system, ensuring adequate perfusion of tissues. This regulation primarily occurs through baroreceptor and chemoreceptor reflexes, involving both short-term and long-term mechanisms.
Baroreceptor Reflex
Baroreceptors, located in the carotid sinuses and aortic arch, detect changes in blood pressure. When blood pressure rises, these stretch-sensitive receptors...
Baroreceptor Reflex
Baroreceptors, located in the carotid sinuses and aortic arch, detect changes in blood pressure. When blood pressure rises, these stretch-sensitive receptors...
2.7K
01:10Homeostatic Imbalance
22.4K
Homeostasis is the maintenance of a stable internal environment within the body, which is crucial for the proper functioning of cells, tissues, organs, and organ systems. The body has various control mechanisms that work together to regulate various physiological parameters such as temperature, blood pressure, pH balance, and fluid balance, to name a few. These control mechanisms are based on feedback loops that can be either positive or negative.
However, sometimes these feedback loops fail,...
However, sometimes these feedback loops fail,...
22.4K
01:12Internal Anatomy of the Kidney
1.5K
The kidneys are essential organs in the human body, performing a myriad of tasks that maintain homeostasis and overall health.
Anatomical Position and Dimensions
The kidneys are retroperitoneal organs positioned against the posterior abdominal wall on either side of the spine, roughly between the twelfth thoracic and third lumbar vertebrae. Each kidney is typically 10-12 cm long, 5-6 cm wide, and 3-4 cm thick, weighing about 150 grams.
Renal Cortex
The outermost region of the kidney is the...
Anatomical Position and Dimensions
The kidneys are retroperitoneal organs positioned against the posterior abdominal wall on either side of the spine, roughly between the twelfth thoracic and third lumbar vertebrae. Each kidney is typically 10-12 cm long, 5-6 cm wide, and 3-4 cm thick, weighing about 150 grams.
Renal Cortex
The outermost region of the kidney is the...
1.5K
01:37Neural Regulation
39.2K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.2K
01:11Enteric Nervous System: Regulation of GI Motor Activity
342
The Enteric Nervous System (ENS) plays a pivotal role in regulating gastrointestinal or GI motor activity. This complex network of nerves, deeply embedded within the gut wall, responds to changes in the gut environment and receives input from both the autonomic nervous system and the central nervous system. By doing so, the ENS operates various programs tailored to the body's nutritional status and needs.
During periods of fasting, the ENS initiates the migrating myoelectric complex, a...
During periods of fasting, the ENS initiates the migrating myoelectric complex, a...
342