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Quantifying irregular pulsation of intracranial aneurysms using 4D-CTA
1School of Mechanical, Medical and Process Engineering, Queensland University of Technology, Brisbane, QLD 4000, Australia; Centre for Biomedical Technologies, Queensland University of Technology, Brisbane, QLD 4000, Australia.
Journal of Biomechanics
|August 11, 2024
Summary
Irregular intracranial aneurysm pulsations, quantified by displacement and strain, show higher strain in ruptured cases. This method aids in assessing aneurysm rupture risk.
Area of Science:
- Biomedical Engineering
- Medical Imaging
- Cardiovascular Research
Background:
- Irregular intracranial aneurysm pulsation is linked to rupture risk.
- Current methods lack quantification for these irregular pulsations.
Purpose of the Study:
- To develop and validate a method for quantifying irregular intracranial aneurysm pulsations.
- To assess displacement and strain distribution on aneurysm surfaces.
Main Methods:
- Utilized four-dimensional CT angiography data from 8 patients.
- Quantified surface displacement and strain using coherent point drift and finite element analysis.
- Compared pulsatile parameters between aneurysms with irregular and normal pulsations.
Main Results:
- Stepwise first principal strain was significantly higher in irregular pulsating aneurysms (0.20±0.01 vs 0.16±0.02, p=0.033).
- Irregular pulsations typically occurred during ascending/descending volume phases.
- No significant difference in overall aneurysm volume change over the cardiac cycle was observed between groups.
Conclusions:
- The developed method successfully quantifies intracranial aneurysm displacement and strain during the cardiac cycle.
- This technique may serve as a valuable tool for assessing aneurysm deformability and rupture risk.
