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  11. Prognostic Impact Of Histological Subtyping In Triple-negative Breast Cancer

Prognostic impact of histological subtyping in triple-negative breast cancer

Claudia Grosse1, Petar Noack1, Alexandra Grosse2

  • 1Department of Pathology and Molecular Pathology, Johannes Kepler University Linz, Kepler University Hospital GmbH, Altenberger Straße 69 and Krankenhausstraße 9, 4040, Linz, Austria.

Human Pathology
|August 11, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

Special histological types (ST) in triple-negative breast cancer (TNBC) significantly impact patient outcomes. Stratifying TNBC ST subtypes is crucial for personalized treatment strategies and improved survival in these rare breast cancer cases.

Area of Science:

  • Oncology
  • Pathology
  • Genetics
Keywords:
Breast cancerPrognostic stratificationTherapy responseTriple-negative phenotype

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Background:

  • Triple-negative breast cancer (TNBC) lacks targeted therapies, making histological subtypes critical for prognosis.
  • Special histological types (ST) within TNBC are increasingly recognized as significant factors influencing patient survival.
  • Understanding the clinicopathological and survival data of TNBC ST is essential for refining treatment approaches.

Purpose of the Study:

  • To evaluate the clinicopathological features and survival outcomes of patients with special histological types (ST) of triple-negative breast cancer (TNBC).
  • To compare the outcomes of TNBC ST subtypes (low-grade, high-grade, apocrine/androgen receptor-positive) with TNBC of no special type (NST).
  • To determine the prognostic significance of TNBC ST for optimizing patient management.

Main Methods:

  • Retrospective analysis of clinicopathological and survival data from 598 patients with 613 TNBCs.
  • Categorization of TNBC into no special type (NST) and special types (ST): low-grade, high-grade, and apocrine/androgen receptor-positive (APO AR).
  • Statistical comparison of patient demographics, Ki67 index, response to neoadjuvant chemotherapy (NAC), and survival outcomes (OS, DFS, DDFS).

Main Results:

  • Patients with low-grade TNBC ST and TNBC ST APO AR were older and had lower Ki67 compared to TNBC NST.
  • High-grade TNBC ST patients were older and showed poorer response to NAC than TNBC NST.
  • Significant survival differences were observed across TNBC ST subtypes and TNBC NST, with low-grade TNBC ST having the best outcomes and high-grade TNBC ST showing worse outcomes than TNBC NST.

Conclusions:

  • Prognostic stratification of triple-negative breast cancer with special histological types is critical.
  • Identifying specific TNBC ST subtypes can guide therapeutic management and improve patient outcomes.
  • Further research into these rare tumor entities is warranted to optimize treatment strategies.
special histological types