Related Experiment Video
Updated: Jun 17, 2025

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
Prenatal diagnosis of critical congenital heart disease associated with lower postpartum depressive symptoms: a
Daniela R Vieira1, Patrícia P Ruschel2, Márcia M Schmidt1
1Instituto de Cardiologia do Rio Grande do Sul- Fundação Universitária de Cardiologia (IC-FUC), Programa de Pós-Graduação em Ciências da Saúde, Cardiologia, Porto Alegre, RS, Brazil.
Objective:
When the expectant mother is faced with an unforeseen event during pregnancy, she may experience emotional fragility and depression. This study was carried out to test the association between the time of diagnosis of critical congenital heart disease (CCHD) and depressive symptoms in puerperal women.
Method:
A case-control study. All mothers answered a semi-structured questionnaire and the Edinburgh Postnatal Depression Scale (EPDS). Pearson's correlation and multiple linear regression analysis were used to determine factors associated with depression.
Results:
50 puerperal women, 23 cases and 27 controls. The proportion of puerperal depressive symptoms was 26.1 % among mothers of infants prenatally diagnosed with CCHD and 77.8 % among mothers of infants postnatally diagnosed (p = 0.001 [OR] 9.917; 95 % CI 2.703-36.379). Multiple linear regression analysis showed that the use of psychotropic drugs and time of diagnosis were significantly associated with puerperal depressive symptoms.
Conclusion:
Prenatal diagnosis of CCHD was associated with significantly lower levels of depressive symptoms.

