Expression and clinical significance of U2AF homology motif kinase 1 in oral squamous cell carcinoma
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View abstract on PubMed
Summary
This summary is machine-generated.U2AF homology motif kinase 1 (UHMK1) is highly expressed in oral squamous cell carcinoma (OSCC) and linked to poor prognosis. This finding suggests UHMK1 may serve as a valuable prognostic marker for OSCC patients.
Area Of Science
- Oncology
- Molecular Biology
- Cancer Research
Background
- U2AF homology motif kinase 1 (UHMK1) is a recently identified molecule with diverse potential functions.
- Aberrant UHMK1 expression is implicated in various cancers and associated with tumor progression.
- UHMK1's role in oral squamous cell carcinoma (OSCC) remains largely unexplored.
Purpose Of The Study
- To investigate the expression levels of UHMK1 in OSCC tissues compared to adjacent non-neoplastic tissues.
- To determine the correlation between UHMK1 expression and clinicopathological features of OSCC.
- To evaluate the prognostic significance of UHMK1 expression on patient survival in OSCC.
Main Methods
- Western blot, quantitative real-time PCR, and immunohistochemistry were employed to assess UHMK1 expression.
- Clinicopathological parameters were analyzed in relation to UHMK1 levels.
- Kaplan-Meier and Cox regression analyses were utilized to assess survival outcomes.
Main Results
- UHMK1 expression was significantly elevated in OSCC tissues versus peritumoral tissues.
- High UHMK1 expression correlated with advanced TNM stage and lymph node metastasis.
- Elevated UHMK1 levels were associated with reduced overall and disease-free survival.
Conclusions
- UHMK1 expression is an independent prognostic factor in OSCC.
- High UHMK1 expression indicates a poorer prognosis for OSCC patients.
- UHMK1 represents a potential prognostic biomarker for oral squamous cell carcinoma.
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