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Updated: Jun 17, 2025

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
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Aberrant alternative splicing in cancer: Splicing events and their regulatory mechanisms (Review)

Yaxuan Sun1, Xiaohui Hu2

  • 1Department of Pathology, School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui 230032, P.R. China.

International Journal of Oncology
|August 12, 2024
PubMed

Insights

Alternative RNA splicing defects drive cancer progression by affecting heterogeneity, apoptosis, metabolism, and metastasis. Understanding these cancer-associated splicing networks offers new therapeutic targets.

Area of Science:

  • Molecular Biology
  • Genetics
  • Cancer Research

Background:

  • Alternative RNA splicing regulates gene expression, contributing to cellular diversity.
  • Aberrant alternative splicing is increasingly linked to cancer development and progression.

Purpose of the Study:

  • To review known alternative splicing events in cancer.
  • To construct splicing regulatory networks for these events.
  • To guide targeted cancer therapies.

Main Methods:

  • Extensive literature search for aberrant alternative splicing events in cancer.
  • Analysis of available data to build splicing regulatory networks.

Main Results:

  • Identified key alternative splicing events influencing cancer heterogeneity, apoptosis, metabolism, and metastasis.
  • Established splicing regulatory networks for multiple cancer-associated splicing events.

Conclusions:

  • Defects in alternative splicing play a significant role in various aspects of cancer progression.
  • Targeting cancer-associated splicing networks presents a promising therapeutic strategy.
Keywords:
alternative RNA splicingcancermetastasisregulatory networksplicing factors

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