High-Throughput Deep Learning Detection of Mitral Regurgitation.
Amey Vrudhula1,2, Grant Duffy1, Milos Vukadinovic1,3
1Department of Cardiology, Smidt Heart Institute (A.V., G.D., M.V., S.C.), Cedars-Sinai Medical Center, Los Angeles, CA.
Circulation
|August 12, 2024
Summary
This study developed an automated deep learning pipeline to detect moderate or severe mitral regurgitation (MR) from echocardiograms. The AI demonstrated high accuracy in identifying MR, offering potential for automated screening.
Area of Science:
- Cardiology
- Artificial Intelligence
- Medical Imaging
Background:
- Diagnosis of mitral regurgitation (MR) relies on echocardiography with Doppler imaging.
- Current diagnostic methods require expert interpretation, highlighting a need for automated solutions.
Purpose of the Study:
- To develop and validate a fully automated deep learning pipeline for MR detection.
- To identify apical 4-chamber view videos with color Doppler and assess MR severity.
Main Methods:
- Utilized a large dataset of 58,614 transthoracic echocardiograms (2,587,538 videos) from Cedars-Sinai Medical Center.
- Developed an automated pipeline for view identification and MR severity assessment.
- Validated the model internally and externally on distinct patient cohorts.
Main Results:
- The view classifier achieved an AUC of 0.998 internally and 0.996 externally.
- The pipeline detected moderate or greater MR with AUCs of 0.916 (internal) and 0.951 (external).
- Severe MR detection showed AUCs of 0.934 (internal) and 0.969 (external).
Conclusions:
- A novel automated pipeline demonstrated excellent performance in identifying significant MR.
- The developed approach shows potential for automated screening and surveillance of mitral regurgitation.
More Related Videos
07:42An Image Guided Transapical Mitral Valve Leaflet Puncture Model of Controlled Volume Overload from Mitral Regurgitation in the Rat
Published on: May 19, 2020
7.0K
11:16In vitro Assessment of Aortic Regurgitation Using Four-Dimensional Flow Magnetic Resonance Imaging
Published on: February 25, 2022
3.3K
Related Concept Videos
01:22Mitral Valve Prolapse II: Assessment and Management
1.4K
IntroductionA range of clinical features characterizes Mitral Valve Prolapse (MVP), but it is important to note that many individuals with MVP are asymptomatic and may remain so throughout their lives. For those who do exhibit symptoms, the following are the key clinical features:Palpitations: This is a common symptom where individuals feel an irregular or rapid heartbeat. Palpitations in MVP are often due to arrhythmias such as premature ventricular contractions or supraventricular...
1.4K
01:20Mitral Regurgitation I: Introduction
1.3K
Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
1.3K
01:23Mitral Regurgitation II: Clinical Features and Diagnostic Tests
943
Mitral regurgitation (MR) is a valvular heart disorder in which the mitral valve fails to close tightly, allowing blood to leak backward into the heart. Understanding the clinical manifestations, assessment, diagnostic findings, and medical management of MR is crucial to effectively managing affected patients.Clinical Manifestations of Mitral RegurgitationMitral regurgitation can be acute or chronic, each presenting differently and requiring different approaches:1. Acute Mitral...
943
01:25Mitral Regurgitation III: Medical Management
686
Mitral regurgitation (MR) is characterized by retrograde blood circulation from the left ventricle into the left atrium due to inadequate mitral valve closure. The severity of the condition, symptoms, and underlying cause determine treatment strategies.Monitoring and Pharmacological TreatmentPatients with mild to moderate MR typically do not need immediate intervention but regular monitoring to assess progression and guide treatment. Patients with mild MR should have an echocardiogram every 3-5...
686
01:28Mitral Regurgitation IV: Nursing Management
602
Mitral regurgitation (MR) is a condition where the mitral valve does not close properly, leading to the backward flow of blood from the left ventricle into the left atrium during systole. This condition can arise from various causes, including rheumatic fever, infective endocarditis, or degenerative valve disease. Effective nursing management is crucial to optimizing patient outcomes and involves comprehensive assessment and targeted interventions.Comprehensive Patient AssessmentA detailed...
602
01:23Mitral Stenosis II: Clinical features and Diagnostic Tests
557
Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
557