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Updated: Jun 17, 2025

Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging
Published on: December 4, 2016
Ion carrier modulated MRI contrast
Anna M Duncan1, Connor M Ellis1, Hannah Levingston1
1Department of Chemistry, University of Oxford South Parks Road Oxford OX1 3QZ UK jason.davis@chem.ox.ac.uk +44(0)1865272690 +44(0)1865275914.
Abstract:
An ion-responsive MRI contrast agent based on a POPC liposomal scaffold is generated that displays a large amplitude relaxivity switch. Entrapment of MR active Gd-DOTA within cholesterol-doped, i.e., membrane rigidified, liposomes dampens the MR response through diminished water exchange across the lipid bilayer. Relaxivity is re-established by integration of ion carriers in the liposome membrane to mediate solvated ion flux.
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