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The PRECISE-DYAD Neurodevelopmental substudy protocol: neurodevelopmental risk in children of mothers with pregnancy
Dorcas N Magai1, Jaya Chandna2, Marie-Laure Volvert3
1Department of Women's and Children's Health, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, England, L12 2AP, UK.
Insights
This study examines how pregnancy complications and environmental factors affect child neurodevelopment in Gambia and Kenya. Findings will identify key intervention points to prevent developmental impairments in early childhood.
Area of Science:
- Global child development
- Maternal and child health
- Neuroscience and developmental biology
Background:
- Over 250 million children globally do not reach their developmental potential.
- The impact of prenatal factors and their interplay with postnatal environmental factors on child neurodevelopment remains unclear, especially in low- and middle-income settings.
- This study investigates pregnancy complications and their influence on neurodevelopmental trajectories.
Purpose of the Study:
- To understand the impact of pregnancy complications on neurodevelopmental trajectories in infants and children.
- To identify environmental, psychosocial, and biological predictors of child neurodevelopment.
- To inform strategic interventions for preventing and reducing neurodevelopmental impairments in low-resource settings.
Main Methods:
- Observational cohort study of approximately 3,950 children born to 4,200 women in Gambia and Kenya.
- Assessment of child neurodevelopment using multiple validated tools at various time points from six weeks to 37 months.
- Statistical analysis including multivariate logistic regression and structural equation modeling to analyze predictors and trajectories.
Main Results:
- (Study results are not yet available in the abstract)
Conclusions:
- Provides crucial data on infant and child neurodevelopment in low-resource African communities.
- Highlights the importance of evaluating developmental trajectories and their predictors.
- Aims to guide targeted interventions to mitigate neurodevelopmental impairments.
Background:
Over 250 million children are not reaching their developmental potential globally. The impact of prenatal factors and their interplay with postnatal environmental factors on child neurodevelopment, is still unclear-particularly in low- and middle-income settings. This study aims to understand the impact of pregnancy complications as well as environmental, psychosocial, and biological predictors on neurodevelopmental trajectories.
Methods:
This is an observational cohort study of female and male children (≈3,950) born to women (≈4,200) with and without pregnancy complications (pregnancy-induced hypertension, foetal growth restriction, and premature birth) previously recruited into PREgnancy Care Integrating Translational Science, Everywhere study with detailed biological data collected in intrapartum and post-partum periods. Children will be assessed at six weeks to 6 months, 11-13 months, 23-25 months and 35-37 months in rural and semi-urban Gambia (Farafenni, Illiasa, and Ngayen Sanjal) and Kenya (Mariakani and Rabai). We will assess children's neurodevelopment using Prechtls General Movement Assessment, the Malawi Development Assessment Tool (primary outcome), Observation of Maternal-Child Interaction, the Neurodevelopmental Disorder Screening Tool, and the Epilepsy Screening tool. Children screening positive will be assessed with Cardiff cards (vision), Modified Checklist for Autism in Toddlers Revised, and Pediatric Quality of Life Inventory Family Impact. We will use multivariate logistic regression analysis to investigate the impact of pregnancy complications on neurodevelopment and conduct structural equation modelling using latent class growth to study trajectories and relationships between biological, environmental, and psychosocial factors on child development.
Conclusions:
We aim to provide information regarding the neurodevelopment of infants and children born to women with and without pregnancy complications at multiple time points during the first three years of life in two low-resource African communities. A detailed evaluation of developmental trajectories and their predictors will provide information on the most strategic points of intervention to prevent and reduce the incidence of neurodevelopmental impairments.
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