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Diffuse large B-cell lymphoma presenting with pulmonary artery compression symptoms, case reports.
Mhd Baraa Habib1, Khaled Ali2, Mohamad Fael1
1Internal Medicine Department Hamad Medical Corporation Doha Qatar.
Respirology Case Reports
|August 12, 2024
Summary
Mediastinal diffuse large B-cell lymphoma (DLBC) can present with pulmonary artery compression. Early recognition of local mass effect symptoms is crucial for timely diagnosis and treatment of this lymphoma subtype.
Area of Science:
- Oncology
- Hematology
- Medical Imaging
Background:
- Mediastinal diffuse large B-cell lymphoma (DLBC) is an aggressive non-Hodgkin lymphoma.
- DLBC can present with diverse clinical manifestations, including systemic and local mass symptoms.
Observation:
- Two cases of DLBC presenting with pulmonary artery compression are detailed.
- Case 1: A 38-year-old man with symptoms mimicking pulmonary embolism.
- Case 2: A 27-year-old woman experiencing syncope and respiratory distress due to mass effect.
Findings:
- Both patients demonstrated significant improvement following treatment for DLBC.
- Local mass effect can be an initial presenting symptom of DLBC, mimicking other conditions.
- Pulmonary artery compression is a potential, under-recognized manifestation of mediastinal DLBC.
Implications:
- Clinicians should consider DLBC in the differential diagnosis of patients with unexplained pulmonary artery compression.
- Recognizing local mass effect symptoms is vital for prompt diagnosis and management of DLBC.
- This highlights the importance of comprehensive evaluation for mediastinal masses presenting with cardiopulmonary symptoms.
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