Prognostic Role of Tumor Budding and Worst Pattern of Invasion in Lymph Node Metastasis and Disease-Free Survival in Oral Squamous Cell Cancer Patients: Result from Central India's Regional Cancer Centre
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.Tumor budding and depth of invasion are key predictors of nodal metastasis in oral squamous cell carcinoma. These factors, along with pattern of invasion, also impact disease-free survival, highlighting their importance in patient prognosis.
Area Of Science
- Oncology
- Pathology
Background
- Oral squamous cell carcinoma (OSCC) is a significant global health concern.
- Accurate prediction of nodal metastasis and disease-free survival is crucial for effective OSCC patient management.
Purpose Of The Study
- To investigate the prognostic value of clinicopathological parameters, specifically pattern of invasion and tumor budding, in OSCC.
- To identify independent predictors of nodal metastasis and disease-free survival in OSCC patients.
Main Methods
- Retrospective analysis of 90 OSCC patients treated surgically.
- Univariate and multivariate logistic regression analyses to assess predictive significance of clinicopathological parameters.
- Kaplan-Meier method and log-rank test for disease-free survival analysis.
Main Results
- Multivariate analysis identified tumor budding, depth of invasion, and perineural invasion as independent predictors of nodal metastasis (p < 0.05).
- Infiltrative pattern of invasion and tumor budding significantly correlated with poorer 3-year disease-free survival (p < 0.05).
- Several factors including grade, T stage, lymphovascular emboli, and pattern of invasion were significant on univariate analysis.
Conclusions
- Tumor budding and worst pattern of invasion are critical prognostic indicators in OSCC.
- These parameters, along with host lymphocyte response, should be incorporated into routine histopathology reporting for OSCC.
- Improved histopathological assessment can enhance risk stratification and guide treatment decisions for OSCC patients.
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
