5-Fluorouracil resistance-based immune-related gene signature for COAD prognosis
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View abstract on PubMed
Summary
This summary is machine-generated.Drug resistance to 5-Fluorouracil (5-FU) chemotherapy is a major challenge in colorectal cancer. A new prognostic model using five genes can predict patient survival and guide targeted therapy for colorectal adenocarcinoma.
Area Of Science
- Oncology
- Genomics
- Bioinformatics
Background
- Drug resistance is a primary obstacle in advanced tumor therapy and a key risk factor for tumor recurrence and death.
- 5-Fluorouracil (5-FU) chemotherapy is a common treatment for colorectal cancer, yet drug resistance remains a significant challenge.
Purpose Of The Study
- To identify genes associated with 5-FU resistance in colorectal cancer.
- To develop a prognostic signature for colorectal adenocarcinoma (COAD) based on these genes.
- To evaluate the therapeutic value of the prognostic signature.
Main Methods
- Utilized Gene Expression Omnibus and The Cancer Genome Atlas Program databases.
- Identified 5-FU resistance-related differentially expressed genes (5FRRDEGs) by intersecting datasets.
- Established a prognostic signature of five 5FRRDEGs using Cox regression analysis.
Main Results
- Identified 166 5FRRDEGs in COAD patients.
- Developed a prognostic model comprising five 5FRRDEGs (GOLGA8A, KLC3, TIGD1, NBPF1, SERPINE1).
- Patients stratified into risk groups showed distinct survival outcomes, with high-risk groups having worse prognoses.
Conclusions
- The 5FRRDEG-based prognostic model is effective for targeted therapy and chemotherapy in COAD patients.
- The model accurately predicts survival prognosis and guides research into COAD resistance mechanisms.
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