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Updated: Jun 17, 2025

Synthesis of Zeolites Using the ADOR Assembly-Disassembly-Organization-Reassembly Route
Published on: April 3, 2016
A Structural Mimic of Carbonic Anhydrase in Zeolitic Imidazolate Frameworks via Trans-functionalization for Enhancing
Fanchen Meng1, Cheng Xu1, Linghai Zhang1
1Key Laboratory of Flexible Electronics (KLOFE), Institute of Advanced Materials (IAM) & School of Flexible Electronics (Future Technologies), Nanjing Tech University, Nanjing 211816, P.R. China.
Abstract:
Metal-organic frameworks (MOFs) have been widely considered as ideal platforms for the preparation of biomimetic catalysts, but it remains challenging to fabricate MOF-based enzyme-like catalysts with optimal activity. Here, we leverage the inherent flexibility of MOFs and propose a novel trans-functionalization strategy to construct a carbonic anhydrase (CA) mimic by the structural transformation from ZIF-L to ZIF-8. Theoretical and experimental results reveal that during the structural transformation, the hydroxyl group will preferentially coordinate with the interlayer Zn clusters to form the CA-like active center Zn-N3-OH. Therefore, more accessible active centers are generated on the as-prepared ZIF-8-OH, resulting in substantially enhanced catalytic activity in the hydrolysis of para-nitrophenyl acetate.
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