Related Experiment Video
Updated: Jun 17, 2025
Body Composition and Metabolic Caging Analysis in High Fat Fed Mice
Published on: May 24, 2018
Comparative metabolomic analysis of mouse plasma in response to different dietary conditions
So Hwi Yang1, Ye Jin Kim1, HanGyeol Lee2
1Division of Life Sciences, College of Life Sciences, and Bioengineering, Incheon National University, Inchon, 22012 Republic of Korea.
Abstract:
Plasma metabolites offer insights into aging processes and aging-related biomarkers. Here, the dietary effects of various functional foods on older adult mice were evaluated using metabolomic techniques. Fifty-week-old mice were divided into four groups (n = 4 each) and fed either a normal diet (AC) or the diets from Triticum aestivum sprout (TA), Schisandra chinensis (SZ), or Pisum sativum sprout (PS) extracts. Additionally, a group of 8-week-old mice fed a normal diet (YC; n = 5) was included for the comparison. The PS group had a significantly lower free fatty acid content and higher ornithine, proline, citric acid, and oxalic acid contents than the AC group. The PS group also showed reduced oxidative stress and muscle damage, suggesting the higher anti-aging efficacy of P. sativum sprouts than the other diets. These findings suggest plasma metabolite profiling is an effective tool to assess the anti-aging effects of functional foods.
Supplementary Information:
The online version contains supplementary material available at 10.1007/s10068-023-01479-8.
