Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance

Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance

The elimination half-life and drug clearance of drugs following nonlinear kinetics can vary with dosage. The Michaelis-Menten parameters and drug concentration influence these factors. As the dose increases, the elimination half-life tends to lengthen, resulting in a reduction in clearance and a disproportionately larger area under the curve. The total clearance can be derived from the Michaelis-Menten equation for drugs following a one-compartment model.
A study on guinea pigs examined the...

Heart Failure Drugs: Inotropic Agents

Heart Failure Drugs: Inotropic Agents

Positive inotropic agents are commonly used as the first line of treatment for heart failure. One such agent is digoxin, derived from the genus Digitalis, which has been known for centuries but effectively utilized since 1785. However, these cardiac glycosides can have potentially toxic effects due to their mechanism of action, which involves inhibiting Na+/K+-ATPase and increasing contractility. Digoxin is absorbed orally and distributed in various tissues, including the CNS. It has a long...

Anticholinesterase Agents: Poisoning and Treatment

Anticholinesterase Agents: Poisoning and Treatment

Anticholinesterases, also known as cholinesterase inhibitors, work by blocking the breakdown of acetylcholine, leading to its accumulation in the synaptic cleft. This accumulation indirectly enhances both muscarinic and nicotinic actions. These agents are classified as reversible or irreversible based on their mechanism of action.
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Comment on "we need a standardized North American acetylcysteine dosing regimen for the treatment of paracetamol (acetaminophen) poisoning".

Clinical toxicology (Philadelphia, Pa.)·2026

Same author

Redefining Hemp: Public Law 119-37 and the Future of Cannabinoid Products.

Journal of medical toxicology : official journal of the American College of Medical Toxicology·2026

Same author

Rhabdomyolysis and Acute Kidney Injury after Use of 3-Methyl-PCP: A Case Report.

Journal of medical toxicology : official journal of the American College of Medical Toxicology·2026

Same author

Use of Methylene Blue to Treat Hypotension in Poisoned Patients in the Toxicology Investigators Consortium (ToxIC) Core Registry: 2016-2023.

Journal of medical toxicology : official journal of the American College of Medical Toxicology·2025

Same author

Trends in alcohol withdrawal management by medical toxicologists in the acute care setting: an analysis of the Toxicology Investigators Consortium (ToxIC) Core Registry, 2016-2022.

Alcohol and alcoholism (Oxford, Oxfordshire)·2025

Same author

Paralysis and Necrotic Wound Infection Resulting From Monocled Cobra Envenomation.

Cureus·2024

Search research articles

Related Experiment Video

Updated: Jun 17, 2025

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids

Published on: April 25, 2016

Equine Pergolide Toxicity: A Case Series.

Natalie E Ebeling-Koning¹, John T Fowler¹, John D DelBianco¹

¹Department of Emergency and Hospital Medicine, Lehigh Valley Health Network/University of South Florida (USF) Morsani College of Medicine, Allentown, USA.

|August 12, 2024

Summary

This summary is machine-generated.

Veterinary medications can cause human toxicity, with pergolide (a horse medication) causing adverse effects in two owners after accidental ingestion. Case reports are crucial for managing such unique poisoning incidents.

Keywords:

dopamine receptor agonist equine pergolide toxicity unintentional ingestion veterinary medication exposure

More Related Videos

Caenorhabditis elegans as a Model System for Discovering Bioactive Compounds Against Polyglutamine-Mediated Neurotoxicity

Caenorhabditis elegans as a Model System for Discovering Bioactive Compounds Against Polyglutamine-Mediated Neurotoxicity

Published on: September 21, 2021

Paw-Print Analysis of Contrast-Enhanced Recordings PrAnCER: A Low-Cost, Open-Access Automated Gait Analysis System for Assessing Motor Deficits

Paw-Print Analysis of Contrast-Enhanced Recordings PrAnCER: A Low-Cost, Open-Access Automated Gait Analysis System for Assessing Motor Deficits

Published on: August 12, 2019

Related Experiment Videos

Last Updated: Jun 17, 2025

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids

Published on: April 25, 2016

Caenorhabditis elegans as a Model System for Discovering Bioactive Compounds Against Polyglutamine-Mediated Neurotoxicity

Caenorhabditis elegans as a Model System for Discovering Bioactive Compounds Against Polyglutamine-Mediated Neurotoxicity

Published on: September 21, 2021

Paw-Print Analysis of Contrast-Enhanced Recordings PrAnCER: A Low-Cost, Open-Access Automated Gait Analysis System for Assessing Motor Deficits

Paw-Print Analysis of Contrast-Enhanced Recordings PrAnCER: A Low-Cost, Open-Access Automated Gait Analysis System for Assessing Motor Deficits

Published on: August 12, 2019

Area of Science:

Veterinary toxicology
Human toxicology
Pharmacology

Background:

Veterinary medications pose risks for human toxicity, with over 6,000 exposures reported in 2022.
Limited literature exists on managing poisoning from equine-specific pharmaceuticals.
Pergolide, used for equine Cushing's disease, was previously withdrawn from human use due to cardiac risks.

Observation:

Two cases of pergolide toxicity in horse owners following unintentional ingestion are presented.
Both patients exhibited similar clinical symptoms after ingesting the veterinary drug.
Veterinary drug ingestions present challenges due to limited human data and differing dosage recommendations.

Findings:

Unintentional pergolide ingestion led to toxic effects in human patients.
Clinical presentations were consistent across both reported cases.
Human toxicity data for veterinary drugs is often scarce.

Implications:

Case reports of human toxicity from veterinary medications are vital for clinical management.
Understanding clinical presentations aids in anticipating patient outcomes.
This highlights the need for increased awareness and data sharing regarding veterinary drug safety in humans.