Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

2.3K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.3K
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

27
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
27
Carbohydrate Metabolism01:36

Carbohydrate Metabolism

10.9K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
10.9K
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

521
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
521
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

2.5K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.5K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

911
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
911

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Weight gain during early adulthood, trajectory of body shape and the risk of nonalcoholic fatty liver disease: A prospective cohort study among women.

Metabolism: clinical and experimental·2020
Same author

Identifying Novel Susceptibility Genes for Colorectal Cancer Risk From a Transcriptome-Wide Association Study of 125,478 Subjects.

Gastroenterology·2020
Same author

Aspirin in the Prevention of Colorectal Neoplasia.

Annual review of medicine·2020
Same author

The Prognostic Role of Macrophage Polarization in the Colorectal Cancer Microenvironment.

Cancer immunology research·2020
Same author

Lifestyle and Environmental Approaches for the Primary Prevention of Hepatocellular Carcinoma.

Clinics in liver disease·2020
Same author

Genetic Variants in the Regulatory T cell-Related Pathway and Colorectal Cancer Prognosis.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology·2020

Related Experiment Video

Updated: Jun 17, 2025

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
06:46

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Published on: September 27, 2024

239

Type 2 Diabetes and Risk of Early-Onset Colorectal Cancer.

Zitong Li1, Hanyu Chen1, Cassandra D L Fritz2

  • 1Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri.

Gastro Hep Advances
|August 12, 2024
PubMed
Summary
This summary is machine-generated.

Type 2 diabetes increases the risk of early-onset colorectal cancer (CRC). This association is stronger with uncontrolled or complicated diabetes, suggesting a link to rising CRC rates in younger adults.

Keywords:
Colorectal CancerDiabetesEarly-onsetEpidemiology

More Related Videos

Generation of High Quality Chromatin Immunoprecipitation DNA Template for High-throughput Sequencing ChIP-seq
09:52

Generation of High Quality Chromatin Immunoprecipitation DNA Template for High-throughput Sequencing ChIP-seq

Published on: April 19, 2013

24.4K
A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
06:46

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

Published on: July 5, 2022

2.7K

Related Experiment Videos

Last Updated: Jun 17, 2025

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
06:46

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Published on: September 27, 2024

239
Generation of High Quality Chromatin Immunoprecipitation DNA Template for High-throughput Sequencing ChIP-seq
09:52

Generation of High Quality Chromatin Immunoprecipitation DNA Template for High-throughput Sequencing ChIP-seq

Published on: April 19, 2013

24.4K
A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
06:46

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

Published on: July 5, 2022

2.7K

Area of Science:

  • Oncology
  • Endocrinology
  • Epidemiology

Background:

  • Early-onset colorectal cancer (CRC) incidence is rising globally.
  • Type 2 diabetes mellitus (T2DM) prevalence is also increasing, particularly in younger populations.
  • The relationship between T2DM and early-onset CRC risk is not well-established.

Purpose of the Study:

  • To investigate the association between type 2 diabetes and the risk of developing early-onset colorectal cancer.
  • To examine if diabetes severity modifies this risk.

Main Methods:

  • A nested case-control study utilized claims data from the IBM MarketScan Commercial Database (2006-2015).
  • Early-onset CRC cases (ages 18-49) were identified using ICD-9 codes.
  • Type 2 diabetes status and severity were determined using ICD-9 codes and the Klabunde algorithm.

Main Results:

  • A total of 6,001 early-onset CRC cases and 52,104 controls were analyzed.
  • Type 2 diabetes was associated with a 24% increased risk of early-onset CRC (OR=1.24).
  • The risk was significantly higher for uncontrolled (OR=1.37) and complicated (OR=1.59) T2DM compared to controlled T2DM.

Conclusions:

  • Individuals with type 2 diabetes face an elevated risk of early-onset colorectal cancer.
  • Uncontrolled and complicated diabetes show a more pronounced association with increased CRC risk.
  • The growing prevalence of type 2 diabetes may be a contributing factor to the rising rates of early-onset CRC.