Ferroptosis-related gene transferrin receptor protein 1 expression correlates with the prognosis and tumor immune microenvironment in cervical cancer
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View abstract on PubMed
Summary
This summary is machine-generated.High expression of Transferrin receptor protein 1 (TFRC) in cervical cancer (CC) correlates with disease progression and poor prognosis. This suggests ferroptosis, influenced by TFRC, is a potential therapeutic target for CC.
Area Of Science
- Oncology
- Cell Death Mechanisms
- Bioinformatics
Background
- Ferroptosis, an iron-dependent cell death, is implicated in cancer, but its role in cervical cancer (CC) progression is unclear.
- Transferrin receptor protein 1 (TFRC) is linked to ferroptosis and various cancers, yet its prognostic value in CC needs investigation.
Purpose Of The Study
- To explore the significance of the ferroptosis-related gene TFRC in the progression and prognosis of cervical cancer using bioinformatics.
- To assess the relationship between TFRC expression, clinical outcomes, and immune cell infiltration in CC.
Main Methods
- Utilized RNA sequencing data from TCGA, GTEx, and GEO databases for CC patients.
- Employed LASSO Cox regression to develop a prognostic model and ssGSEA for immune cell infiltration analysis.
- Validated TFRC mRNA and protein expression via qPCR and immunohistochemistry in CC tissues.
Main Results
- CC tissues exhibited significantly higher TFRC gene and protein expression compared to normal tissues.
- Elevated TFRC expression was associated with advanced cancer stages and shorter overall survival (OS).
- Multivariate analysis confirmed high TFRC expression as an independent predictor of poor OS in CC patients.
Conclusions
- Increased TFRC expression in CC is linked to disease progression, unfavorable prognosis, and altered immune cell infiltration.
- Ferroptosis, modulated by TFRC, represents a potential therapeutic avenue for cervical cancer treatment.
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