Related Experiment Video
Updated: Jun 17, 2025
28:13
Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
Published on: February 26, 2013
33.4K
Cardioneuroablation: the known and the unknown.
A Marrese1, R Persico1, E Parlato1
1Department of Cardiology, University of Naples Federico II, Naples, Italy.
Frontiers in Cardiovascular Medicine
|August 12, 2024
Summary
Cardioneuroablation (CNA) offers a new treatment for vasovagal syncope (VVS) and heart block by targeting cardiac nerves. This innovative procedure aims to reduce excessive vagal activity and improve patient outcomes.
Area of Science:
- Cardiology
- Interventional Electrophysiology
- Autonomic Nervous System
Background:
- Vasovagal syncope (VVS) and advanced atrioventricular block can result from excessive vagal tone.
- Current treatments may be insufficient for specific patient populations, particularly young individuals.
Purpose of the Study:
- To provide a comprehensive review of Cardioneuroablation (CNA) for VVS and related conditions.
- To examine the clinical applications, targets, endpoints, and outcomes of CNA.
- To discuss the future perspectives of this novel interventional procedure.
Main Methods:
- Review of existing clinical evidence on Cardioneuroablation.
- Analysis of studies focusing on ablation targets and procedural success.
- Evaluation of medium-to-long term effects and patient outcomes.
Main Results:
- Cardioneuroablation (CNA) shows potential in mitigating excessive vagal activity by targeting cardiac parasympathetic ganglia.
- The procedure aims to improve outcomes for patients with recurrent VVS and atrioventricular block.
- Limited clinical data and lack of guideline recommendations highlight the need for further research.
Conclusions:
- Cardioneuroablation is a promising interventional technique for specific autonomic dysfunction disorders.
- Further research and clinical data are essential to establish its efficacy and safety.
- Expert consensus and guideline integration are needed for wider adoption of CNA.
Related Concept Videos
01:30Cardiac Action Potential
1.2K
Cardiac action potentials are essential for proper heart function, enabling the rhythmic contractions needed for adequate blood circulation. Nodal cells and Purkinje fibers, specialized for electrical conduction, generate these action potentials.
The cardiac action potential process involves a series of phases characterized by the movement of ions across the cardiac cell membranes, leading to the depolarization and repolarization of the cardiac myocytes.
Ionic Basis of Cardiac Action Potentials
The cardiac action potential process involves a series of phases characterized by the movement of ions across the cardiac cell membranes, leading to the depolarization and repolarization of the cardiac myocytes.
Ionic Basis of Cardiac Action Potentials
1.2K
01:19Electrophysiology of Normal Cardiac Rhythm
2.6K
The normal cardiac rhythm is a synchronized electrical activity that facilitates the regular and coordinated contraction of the heart muscle. This process is essential for efficient blood circulation throughout the body. The fundamental elements involved in establishing and maintaining this rhythm include the unique electrical properties of cardiac muscle cells, the sinoatrial (SA) node's pacemaker function, the specialized conducting system, and the ionic mechanisms underlying each phase...
2.6K
01:26Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
406
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
406
01:28Disturbances in Heart Rhythm
924
Arrhythmia or dysrhythmia refers to an abnormal heart rhythm caused by a defect in the heart's conduction system. It can cause the heart to beat irregularly, too quickly, or too slowly, leading to symptoms like chest pain, shortness of breath, and fainting. Factors such as stress, caffeine, alcohol, nicotine, cocaine, certain drugs, congenital defects, diseases, and electrolyte abnormalities can trigger arrhythmias.
Arrhythmias are categorized by their speed, rhythm, and origin. A slow...
Arrhythmias are categorized by their speed, rhythm, and origin. A slow...
924