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Surgical and Endovascular Therapies for Below-the-Knee Peripheral Arterial Disease: A Contemporary Review
Robert S Zilinyi1, Marissa Alsaloum2, Daniel J Snyder2
1Division of Cardiology, Department of Medicine, NewYork-Presbyterian/Columbia University Irving Medical Center, New York, New York.
Insights
Peripheral arterial disease (PAD) is a common cardiovascular issue. This review covers revascularization for below-the-knee PAD, focusing on endovascular techniques and emerging devices for chronic limb-threatening ischemia.
Area of Science:
- Cardiovascular Medicine
- Vascular Surgery
- Interventional Cardiology
Background:
- Peripheral arterial disease (PAD) is a widespread cardiovascular condition associated with significant morbidity and mortality.
- Chronic limb-threatening ischemia (CLTI), the most severe form of PAD, particularly affects patients with below-the-knee (BTK) PAD.
- BTK PAD patients face higher CLTI risks due to small vessel size and common comorbidities like diabetes and end-stage renal disease.
Purpose of the Study:
- To review modern surgical and endovascular revascularization strategies for BTK PAD.
- To discuss current and emerging devices for treating CLTI in BTK PAD patients.
- To provide an overview of the standard of care evolution in BTK PAD management.
Main Methods:
- Review of current literature on surgical and endovascular revascularization for BTK PAD.
- Analysis of the evolution of treatment modalities from surgical bypass to endovascular techniques.
- Examination of adjunctive devices and therapies used in modern endovascular interventions.
Main Results:
- Endovascular techniques have become the standard of care for most CLTI cases in BTK PAD.
- Surgical bypass was the historical standard but is now complemented by less invasive endovascular approaches.
- A range of devices and therapies enhance the efficacy of endovascular revascularization.
Conclusions:
- Endovascular revascularization represents a significant advancement in managing BTK PAD with CLTI.
- Ongoing development of new devices promises further improvements in treatment outcomes.
- Comprehensive understanding of both surgical and endovascular options is crucial for optimal patient care.
Abstract:
Peripheral arterial disease (PAD) represents one of the most prevalent cardiovascular disease processes and carries a high burden of morbidity and mortality. Patients with chronic limb-threatening ischemia (CLTI), the most severe manifestation of PAD, have the highest rates of cardiovascular morbidity and mortality of the overall PAD population. Patients with below-the-knee (BTK) PAD have an increased propensity toward CLTI due to small-vessel caliber and the frequently comorbid conditions of end-stage renal disease and diabetes mellitus, which tend to affect small artery beds preferentially. For those with BTK PAD with CLTI, the standard of care is revascularization. Early revascularization was performed using surgical bypass. However, endovascular techniques, starting with percutaneous transluminal angioplasty and expanding to the modern armamentarium of adjunctive devices and therapies, have become standard of care for most patients with CLTI due to BTK PAD. In this review, we will discuss the modern surgical and endovascular approaches to revascularization, as well as devices that are currently in development or preapproval study for the treatment of BTK PAD.
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