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[Morphological research on DMSO-perfused kidneys].

J Schabel, H Pressler, H J Holzhausen

Zeitschrift Fur Urologie Und Nephrologie

|December 1, 1985

Summary

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Dimethyl sulfoxide (DMSO) cryoprotection of kidneys causes cell changes, similar to non-DMSO methods. Optimal kidney function after storage requires sufficient cryoprotectant and efficient DMSO removal during reperfusion.

Area of Science:

Nephrology
Transplantation immunology
Cell biology

Context:

Kidney preservation for transplantation is crucial.
Cryoprotective agents like dimethyl sulfoxide (DMSO) are used.
Understanding cellular effects of cryopreservation is vital.

Purpose:

To investigate the morphological changes in kidneys preserved with DMSO.
To evaluate the impact of cold storage and DMSO on kidney tissue.
To correlate morphological findings with potential functional recovery.

Summary:

Kidneys perfused with dimethyl sulfoxide (DMSO) and stored at -4.5°C for 72 hours were examined.
Light and electron microscopy revealed significant changes in proximal tubule and collecting tubule cells.

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These DMSO-induced changes, including basal labyrinth dilatation and cytoplasmic vacuolization, suggest passive substance transport.

Impact:

DMSO cryopreservation results in cellular alterations comparable to non-DMSO methods.
Successful kidney retransplantation and function depend on optimal perfusion and reperfusion strategies.
Efficient DMSO removal during reperfusion is critical to minimize osmotic stress and support kidney function recovery.