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Related Experiment Video

Updated: Jun 17, 2025

In Situ Detection of Bacteria within Paraffin-embedded Tissues Using a Digoxin-labeled DNA Probe Targeting 16S rRNA

In Situ Detection of Bacteria within Paraffin-embedded Tissues Using a Digoxin-labeled DNA Probe Targeting 16S rRNA

Published on: May 21, 2015

Linking periodontal pathogens with endoperio lesions.

Sakshi Malik¹, K Sai Priyanka², Rinkee Mohanty³

¹Department of Pediatric and Preventive Dentistry, Daswani Dental College and Research Centre, Kota, Rajasthan, India.

|August 12, 2024

Summary

This study investigated the link between periodontal infections and endodontic-periodontal diseases. Key bacteria like Porphyromonas gingivalis were found in most cases, suggesting dentinal tubules facilitate microbial spread.

Keywords:

Dentinal tubules Endodo-perio lesion Porphyromonas gingivalis Tannerella forsythia

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Last Updated: Jun 17, 2025

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Published on: May 21, 2015

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Induction of Periodontitis via a Combination of Ligature and Lipopolysaccharide Injection in a Rat Model

Published on: February 17, 2023

Area of Science:

Dentistry
Microbiology
Oral Pathology

Background:

Endodontic-periodontal diseases present diagnostic and prognostic challenges.
Understanding the relationship between periodontal infections and endodontic lesions is crucial.

Purpose of the Study:

To correlate periodontal infections with endodontic-periodontal disorders.
To investigate the presence of specific bacteria in teeth with combined lesions.

Main Methods:

A polymerase chain reaction (PCR) experiment was conducted on 50 patients with co-existing endodontic and periodontal lesions.
Bacterial identification focused on Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, and Tannerella forsythia.

Main Results:

Isolates of Porphyromonas gingivalis were identified in 91% of periodontium samples.
Aggregatibacter actinomycetemcomitans and Tannerella forsythia were found in 12% and 51% of endodontium samples, respectively.
The targeted bacterial species were significantly associated with concurrent periodontal and endodontic disorders.

Conclusions:

Dentinal tubules likely act as a pathway for microbial dissemination between periodontal and endodontic sites.
The findings support a microbial link in the pathogenesis of endodontic-periodontal diseases.