Related Experiment Video
Updated: Jun 25, 2026

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets
Published on: November 29, 2024
Toluene exposure and changes in platelet count: a narrative review
Gabriel Machado Romão da Silva1, Eric Slawka1, Aline de Souza Espíndola Santos2
1Faculdade de Medicina, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil.
Abstract:
Toluene is a widely used solvent whose many toxic effects include neurological and hematological damage. This study reviewed evidence about the effects of toluene exposure on platelet count in humans. Three electronic databases and a digital library of theses and dissertations were searched using a specific strategy, yielding 64 articles, of which 14 were selected. These studies assessed a total of 15,759 participants, including 13,297 exposed individuals, mainly women exposed in an environmental setting. The major findings were: (1) conflicting results (positive, inverse, or no association), (2) cross-contamination with other substances, which impaired assessment of the relationship, and (3) a lack of studies. Thus, further research is needed on this topic, especially toluene exposure in isolation from associated substances.
Related Concept Videos
Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu
Drug toxicity: Idiosyncratic Reactions
Toxicity Testing in Animals

