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Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

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Genetic profiling in radiotherapy: a comprehensive review.

Dino Rubini¹, Federico Gagliardi¹, Vittorio Salvatore Menditti¹

¹Department of Precision Medicine, University of Campania "L. Vanvitelli", Naples, Italy.

Frontiers in Oncology

|August 12, 2024

Summary

Genetic profiling revolutionizes radiotherapy by identifying markers for radiation toxicity and personalizing cancer treatment. This approach enhances treatment response, prognosis, and resistance, advancing precision medicine in oncology.

Keywords:

genomic profiling profiling radiation oncology (RO)radiogenomics radiotherapy

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Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

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Published on: February 6, 2019

Area of Science:

Oncology
Genetics
Radiotherapy

Background:

Radiotherapy is a cornerstone of cancer treatment.
Genetic factors influence individual responses to cancer therapies.
Personalized medicine aims to tailor treatments based on patient-specific characteristics.

Purpose of the Study:

To review the role of genetic profiling in radiotherapy.
To highlight genetic markers for predicting radiation toxicity.
To explore the impact of genetic profiling on radiotherapy strategies and outcomes across various cancer types.

Main Methods:

Comprehensive literature review of studies on genetic profiling and radiotherapy.
Analysis of research findings on genetic markers, treatment response, prognosis, and resistance.
Synthesis of evidence on the integration of genetic profiling into radiotherapy planning.

Main Results:

Genetic profiling identifies key markers for predicting radiation toxicity.
Genetic profiling impacts radiotherapy strategies, influencing treatment response and prognosis.
Evidence supports the use of genetic profiling to overcome therapeutic resistance.

Conclusions:

Genetic profiling is transforming cancer treatment paradigms.
Personalized radiotherapy regimens can be developed using genetic insights.
Integrating genetic profiling enhances patient outcomes and advances precision oncology.