Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Myasthenia Gravis: Overview and Treatment

Myasthenia Gravis: Overview and Treatment

Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...

Other Pulmonary Disorders

Other Pulmonary Disorders

Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation

Myasthenia Gravis: Diagnostic Tests

Myasthenia Gravis: Diagnostic Tests

Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...

Disorders of the Skeletal Muscle

Disorders of the Skeletal Muscle

The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...

Pleural Disorders: Types and Brief Description

Pleural Disorders: Types and Brief Description

The pleura is a vital part of the respiratory system. It's a double-layered membrane surrounding the lungs and lining the chest cavity. The two layers of the pleura are:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Multicentre international audit of IMACS malignancy screening guidelines in idiopathic inflammatory myopathies: insights from the myositis audit and research collaborative group.

RMD open·2026

Same author

Expert viewpoint on endpoints in systemic sclerosis: current and future outlook.

RMD open·2026

Same author

Phenotype-specific associations of mosaic chromosomal alterations in systemic sclerosis.

Annals of the rheumatic diseases·2026

Same author

JCS/JPCPHS 2025 Guideline on Pulmonary Hypertension and Pulmonary Embolism/Deep Vein Thrombosis.

Circulation journal : official journal of the Japanese Circulation Society·2026

Same author

Critical ischemia of multiple organ systems in a patient with systemic lupus erythematosus complicated by catastrophic antiphospholipid syndrome: Potential pathogenetic role of non-inhibitory anti-ADAMTS13 autoantibodies.

Modern rheumatology case reports·2026

Same author

Concordance for myositis-specific autoantibody detection between commercial ELISA and line blot assays: a multicentre study conducted across the Asia-Pacific region.

Rheumatology (Oxford, England)·2026

Search research articles

Related Experiment Video

Updated: Jun 17, 2025

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Interstitial lung disease and myositis.

Takahisa Gono^1,2, Masataka Kuwana^1,2

¹Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine.

Current Opinion in Rheumatology

|August 12, 2024

Summary

Interstitial lung disease (ILD) is a major concern in myositis patients. Recent findings highlight risk factors and screening methods for myositis-ILD, guiding personalized treatment strategies.

More Related Videos

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

Induction of Mouse Lung Injury by Endotracheal Injection of Bleomycin

Induction of Mouse Lung Injury by Endotracheal Injection of Bleomycin

Published on: April 30, 2019

Related Experiment Videos

Last Updated: Jun 17, 2025

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

Induction of Mouse Lung Injury by Endotracheal Injection of Bleomycin

Induction of Mouse Lung Injury by Endotracheal Injection of Bleomycin

Published on: April 30, 2019

Area of Science:

Rheumatology and Pulmonology
Autoimmune Diseases
Interstitial Lung Disease

Background:

Interstitial lung disease (ILD) significantly contributes to morbidity and mortality in myositis patients.
Current treatment strategies for myositis-associated ILD require refinement due to limited evidence.
This review addresses the urgent need for updated management approaches.

Purpose of the Study:

To review recent advancements in the management of myositis-associated ILD.
To focus on key areas including screening, risk stratification, and treatment protocols.
To provide an updated perspective for clinicians managing these complex cases.

Main Methods:

Literature review of recent studies on myositis-ILD management.
Analysis of identified risk factors for ILD development in myositis.
Examination of proposed screening tools and treatment algorithms.

Main Results:

Identified risk factors for ILD in myositis include Asian race/residence, dermatomyositis, mechanic's hand, and specific autoantibodies (antisynthetase, anti-MDA5).
High-resolution computed tomography (HRCT) is recommended for screening patients with these risk factors.
While prediction models for mortality and rapidly progressive ILD (RP-ILD) exist, further validation is needed. Tentative treatment algorithms have been proposed by major academic societies.

Conclusions:

Accumulating knowledge on risk stratification aids in personalized management of myositis-ILD.
Global collaborative efforts are essential to establish robust evidence for consensus-based treatment algorithms.
Further research is needed to refine and validate management strategies for myositis-associated ILD.