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Related Experiment Video

Updated: Jun 17, 2025

Noninvasive, High-throughput Determination of Sleep Duration in Rodents
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Insomnia and sleep duration for kidney function: Mendelian randomization study.

Yang Zhang1, Zhaozhong Zhong2, Zuofu Tang1

  • 1Department of Kidney Transplantation, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.

Renal Failure
|August 12, 2024
PubMed
Summary

Insomnia and short sleep duration increase the risk of elevated serum creatinine. Longer sleep duration positively impacts serum creatinine and kidney function (eGFRcys, cystatin C), with potential indirect effects on kidney disease markers mediated by obesity.

Keywords:
Kidney functionMendelian randomizationinsomniasleep duration

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Area of Science:

  • Nephrology
  • Sleep Medicine
  • Genetics

Background:

  • Sleep disorders like insomnia and insufficient sleep duration are linked to kidney dysfunction.
  • Establishing a definitive causal link between sleep patterns and kidney health remains a research challenge.

Purpose of the Study:

  • To investigate the causal relationship between insomnia, sleep duration, and kidney function using Mendelian randomization (MR).
  • To explore potential mediating roles of obesity in the sleep-kidney relationship.

Main Methods:

  • Utilized a two-sample MR approach with genetic variants from large genome-wide association studies (GWAS) for insomnia and sleep duration.
  • Assessed various kidney function parameters including serum creatinine, eGFRcys, and markers of kidney damage.
  • Employed multivariable MR to identify potential mediators like obesity.

Main Results:

  • Found robust evidence that insomnia and short sleep duration causally increase the risk of elevated serum creatinine.
  • Identified causal links between sleep duration and improved serum creatinine, eGFRcys, and cystatin C levels.
  • Observed potential indirect effects on acute renal failure (ARF), chronic renal failure (CRF), microalbuminuria, and β2 microglobulin, possibly mediated by obesity.

Conclusions:

  • Insomnia causally impacts elevated serum creatinine risk.
  • Adequate sleep duration positively influences serum creatinine, eGFRcys, and cystatin C.
  • Obesity may mediate the indirect effects of sleep on specific kidney disease indicators.