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A Real-Time Wearable Electromyography Measurement System for Small Animals
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Potential value of animal microphysiological systems.

Paul C Brown1, Barry H Hooberman2, Brianna L Skinner3

  • 1U.S. Food and Drug Administration, Center for Drug Evaluation and Research, Silver Spring, MD, USA.

ALTEX
|August 12, 2024
PubMed
Summary
This summary is machine-generated.

Animal microphysiological systems (MPS) offer value in studying diseases and therapeutics, supporting regulatory decisions, and reducing animal use. Developing animal MPS aids in validating human MPS and identifying species-specific effects.

Keywords:
MPSNAMschipmultiple speciesregulatory

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Area of Science:

  • Biomedical Engineering
  • Toxicology
  • Veterinary Medicine

Background:

  • Microphysiological systems (MPS) mimic in vivo physiology for product safety and efficacy assessment.
  • Significant progress exists for human organ MPS, but a gap remains in animal tissue-based MPS development.
  • Animal MPS can advance zoonotic disease research and animal therapeutic evaluations.

Purpose of the Study:

  • To highlight the potential value and applications of animal-derived microphysiological systems (MPS).
  • To address the gap in the development and utilization of animal MPS.
  • To explore how animal MPS can support regulatory decision-making and the 3Rs principles.

Main Methods:

  • Review of current advancements in microphysiological systems (MPS) technology.
  • Discussion of the potential applications of animal MPS in research and regulatory contexts.
  • Exploration of comparative analysis between animal MPS and in vivo data.

Main Results:

  • Animal MPS show promise for studying zoonotic diseases and assessing animal therapeutics.
  • Development of animal MPS can facilitate comparison with existing animal in vivo data.
  • Animal MPS can aid in identifying species-specific toxicological effects.

Conclusions:

  • Animal MPS development is crucial for advancing comparative physiology and toxicology.
  • Animal MPS contribute to the replacement, reduction, and refinement (3Rs) of animal testing.
  • Animal MPS enhance confidence in human MPS data for regulatory applications.