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Published on: September 27, 2024
Multimorbidities in COPD are Associated With Increased Exacerbations and Health Care Resource Utilization in
Jamuna K Krishnan1, Fernando J Martinez1, Pablo Altman2
1Division of Pulmonary and Critical Care Medicine, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York City, New York, United States.
Chronic obstructive pulmonary disease (COPD) patients with gastroesophageal reflux disease, diabetes, or osteoporosis experience more frequent exacerbations and higher healthcare use. Addressing systemic effects of COPD may improve patient outcomes and reduce exacerbations.
Area of Science:
- Pulmonary Medicine
- Internal Medicine
- Epidemiology
Background:
- Chronic obstructive pulmonary disease (COPD) is associated with systemic morbidities.
- Understanding the impact of comorbidities on COPD exacerbations and healthcare resource utilization (HCRU) is crucial.
Purpose of the Study:
- To investigate the relationship between common comorbidities in COPD patients and their impact on exacerbations and HCRU.
- To analyze real-world data on multimorbidities in COPD.
Main Methods:
- Retrospective, noninterventional cohort study using real-world data.
- Age- and weight-matched cohorts of COPD patients with and without specific comorbidities (GERD, diabetes, osteoporosis/osteopenia) were compared.
- Analysis of COPD exacerbations and COPD-related HCRU over a 5-year follow-up period.
Main Results:
- COPD patients exhibited higher prevalence of GERD, diabetes, and osteoporosis/osteopenia compared to non-COPD cohorts.
- COPD patients with GERD, diabetes, or osteoporosis/osteopenia had significantly increased odds of moderate, severe, and any exacerbations.
- These comorbidities were also associated with significantly increased odds of COPD-related emergency department visits and hospitalizations.
Conclusions:
- GERD, diabetes, and osteoporosis are prevalent in COPD patients and significantly increase exacerbation frequency and HCRU.
- Investigating and addressing the systemic effects of COPD is recommended to improve patient management and reduce exacerbations.
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