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[Necrotizing soft tissue infections].

Christian Lanckohr1, Dagmar Horn2, Steffen Roßlenbroich3

  • 1Antibiotic Stewardship (ABS)-Team, Institut für Hygiene, Universitätsklinikum Münster, Robert-Koch-Straße 41, 48149, Münster, Deutschland. Christian.lanckohr@ukmuenster.de.

Die Anaesthesiologie
|August 12, 2024
PubMed
Summary

Necrotizing soft tissue infections are severe bacterial infections requiring immediate surgical and antimicrobial treatment due to high mortality. Survivors often face long-term functional impairments and require extensive reconstructive surgery.

Keywords:
AntibioticsFasciitisNecrotizing soft tissue infectionPlastic surgerySepsis

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Area of Science:

  • Infectious Diseases
  • Surgical Pathology
  • Critical Care Medicine

Context:

  • Necrotizing soft tissue infections (NSTIs) are severe, rapidly progressing bacterial infections affecting skin, connective tissue, and muscles.
  • These infections present as a time-sensitive emergency with high mortality rates, often necessitating intensive care unit admission.

Purpose:

  • This review provides a comprehensive overview of necrotizing soft tissue infections.
  • It details current knowledge on diagnostics, treatment strategies, and post-treatment care for these complex infections.

Summary:

  • NSTIs involve necrotic tissue destruction caused by various bacterial pathogens across the body.
  • Essential management includes rapid, radical surgical debridement and timely, adequate antimicrobial therapy.
  • Interprofessional collaboration is crucial throughout all disease phases.

Impact:

  • Prompt and effective treatment is vital to reduce mortality and minimize severe functional impairments in survivors.
  • Extensive soft tissue damage often necessitates significant reconstructive plastic surgery follow-up.
  • Understanding NSTI complexities guides improved patient outcomes and rehabilitation.