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A Rapid and Specific Microplate Assay for the Determination of Intra- and Extracellular Ascorbate in Cultured Cells
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Ferrous ascorbate non-effervescent floating mini-caplets as an oral iron supplement.

Shital Trivedi1,2, Vijay Kevlani3, Shreeraj Shah4

  • 1Research Scholar, Gujarat Technological University, Ahmedabad, 382424, Gujarat, India.

Drug Delivery and Translational Research
|August 12, 2024
PubMed
Summary

New non-effervescent floating Ferrous Ascorbate (FA) mini-caplets were developed to enhance iron bioavailability. These floating mini-caplets demonstrated improved in vivo iron absorption compared to immediate-release formulations.

Keywords:
Ferrous ascorbateFloatingGastroretentiveMini-capletPrecirolSerum iron

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Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems
  • Biopharmaceutics

Background:

  • Immediate-release iron products often suffer from poor bioavailability.
  • Ferrous Ascorbate (FA) is a common iron supplement with bioavailability challenges.
  • Gastric retention can improve drug absorption.

Purpose of the Study:

  • To develop non-effervescent floating mini-caplets of Ferrous Ascorbate (FA).
  • To enhance the bioavailability of Ferrous Ascorbate using low-density polymers.
  • To overcome the limitations of immediate-release iron formulations.

Main Methods:

  • Formulation development using melt granulation and low-density polymers.
  • Optimization using a full factorial 3^2 experimental design.
  • Evaluation through in vitro drug release, accelerated stability, and in vivo studies in rabbits.

Main Results:

  • Optimized formulation (F6) exhibited instant and 12-hour floating duration in 0.1N HCl.
  • In vitro drug release followed a diffusion mechanism, with 30-35% release at 1h and 65-70% at 5h.
  • In vivo studies showed significantly increased serum iron and decreased UIBC compared to controls.

Conclusions:

  • Non-effervescent floating FA mini-caplets significantly enhance iron bioavailability compared to immediate-release formulations.
  • Prolonged iron release in the gastric region due to floating contributes to improved absorption.
  • This novel formulation presents a promising approach for managing iron deficiency.