Interfacially Self-Assembled Mutifunctional Protein Thin Films for Accelerated Wound Healing

Area of Science:

• Biomaterials Science
• Nanotechnology
• Surface Chemistry

Background:

• Designing multifunctional protein films for biomedical applications requires scalable fabrication methods.
• Interfacial self-assembly offers a promising approach for creating ordered nanostructures.

Discussion:

• Interfacial electrostatic self-assembly of bovine serum albumin (BSA)-coated nanoclusters with cetyltrimethylammonium bromide (CTAB) forms large-scale protein thin films.
• The protein film exhibits multienzyme activity, potent antibacterial properties, and pH-responsive drug release.
• The film's synergistic effects accelerate wound closure by managing blood glucose, oxidative stress, bacterial load, and promoting cell proliferation.

Key Insights:

• A scalable method for constructing large-area, spatially ordered protein films was demonstrated.
• The developed protein film possesses a unique combination of therapeutic functionalities.
• The film effectively accelerates wound healing through multiple biological mechanisms.

Outlook:

• Further investigation into the long-term stability and in vivo efficacy of these protein films is warranted.
• Exploration of alternative protein sources and assembly strategies could broaden applications.
• This platform technology holds potential for advanced wound care and regenerative medicine.