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Correlation between myelin basic protein levels in cerebrospinal fluid and motor speed in patients with schizophrenia

Takako Enokida1,2, Kotaro Hattori1,3, Miho Ota4,5

  • 1Department of Bioresources, Medical Genome Center, National Center of Neurology and Psychiatry, Tokyo, Japan.

Neuropsychopharmacology Reports
|August 12, 2024
PubMed

Insights

Cerebrospinal fluid myelin basic protein (CSF-MBP) levels did not differ between schizophrenia patients and controls. However, higher CSF-MBP correlated with poorer motor speed and regional white matter changes in schizophrenia patients.

Area of Science:

  • Neuroscience
  • Biomarker Research
  • Schizophrenia Studies

Background:

  • White matter alterations are implicated in schizophrenia.
  • Myelin basic protein (MBP) in cerebrospinal fluid (CSF) is a potential biomarker for white matter damage.

Purpose of the Study:

  • To investigate cerebrospinal fluid MBP (CSF-MBP) levels in schizophrenia patients.
  • To explore the relationship between CSF-MBP, cognition, and white matter integrity in schizophrenia.

Main Methods:

  • Analyzed CSF-MBP levels in 152 schizophrenia patients and 117 controls.
  • Correlated CSF-MBP with age, motor speed (Brief Assessment of Cognition in Schizophrenia), and white matter integrity (diffusion MRI).

Main Results:

  • No significant difference in CSF-MBP levels between patients and controls.
  • CSF-MBP positively correlated with age in both groups.
  • In schizophrenia patients, higher CSF-MBP correlated with lower age-adjusted motor speed and reduced mean kurtosis in the right temporo-parietal white matter.

Conclusions:

  • CSF-MBP has limited utility as a diagnostic marker for schizophrenia.
  • Elevated CSF-MBP levels in schizophrenia are associated with impaired motor speed and regional white matter abnormalities.
Keywords:
cerebrospinal fluiddemyelinationmotor speedmyelin basic proteinschizophrenia

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