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Immunofluorescent and histologic study of cold urticaria
Archives of Dermatological Research
|January 1, 1985
Summary
Cold urticaria biopsies reveal two distinct lesion types, one with neutrophils and another with lymphocytes. Immunofluorescence studies yielded nonspecific or negative findings in most cases.
Area of Science:
- Dermatology
- Immunology
- Pathology
Background:
- Cold urticaria is a physical urticaria triggered by cold exposure.
- The histopathological features of cold urticaria lesions require further elucidation.
Purpose of the Study:
- To investigate the cellular composition and immunofluorescence findings in cold urticaria lesions.
Main Methods:
- Biopsies were obtained from spontaneous and ice-induced wheals in five patients with cold urticaria.
- Histopathological examination focused on predominant cell types (neutrophils vs. lymphocytes).
- Immunofluorescent studies were performed on the biopsy specimens.
Main Results:
- Two distinct histopathological patterns were observed: lesions predominantly infiltrated by neutrophils and lesions predominantly infiltrated by lymphocytes.
- Immunofluorescence studies showed nonspecific findings in two cases and were negative in three cases.
Conclusions:
- Cold urticaria lesions can exhibit diverse cellular infiltrates, suggesting variedPathogenic mechanisms.
- Immunofluorescence is not consistently informative in diagnosing cold urticaria based on these findings.