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IL10 and CXCL10 mRNA expression in food protein-induced enterocolitis syndrome

Ilaria Galliano1, Paola Montanari1, Giovanna Monti2

  • 1Department of Pediatric Sciences and Public Health, University of Turin, Piazza Polonia 94, Turin, Italy.

Cytokine
|August 12, 2024
PubMed

Insights

Food protein-induced enterocolitis syndrome (FPIES) involves immune system changes. FPIES patients show high CXCL10 and low IL-10, suggesting these as potential diagnostic markers.

Area of Science:

  • Immunology
  • Pediatric Allergy

Background:

  • Food protein-induced enterocolitis syndrome (FPIES) is a rare non-IgE-mediated food allergy affecting infants and toddlers.
  • The precise immune mechanisms driving FPIES remain unclear.
  • Investigating cytokine expression, such as IL-10 and CXCL10, offers insight into FPIES pathogenesis.

Purpose of the Study:

  • To investigate the expression levels of IL-10 and CXCL10 in pediatric FPIES patients.
  • To explore the potential of these cytokines as biomarkers for FPIES.

Main Methods:

  • Peripheral venous blood samples were collected from pediatric FPIES patients and healthy controls.
  • Total RNA was extracted, and mRNA levels of CXCL10 and IL-10 were quantified using real-time PCR.

Main Results:

  • Children with FPIES exhibited significantly higher CXCL10 mRNA levels compared to healthy controls.
  • Conversely, FPIES patients displayed significantly lower IL-10 mRNA levels than the control group.

Conclusions:

  • FPIES patients demonstrate elevated CXCL10 and reduced IL-10 production prior to achieving tolerance.
  • These distinct cytokine profiles may serve as valuable molecular diagnostic markers for FPIES.
Abstract

Keywords:
CXCL10ChildrenFood protein–induced enterocolitis syndrome (FPIES)IL10

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