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Updated: Jun 17, 2025

Author Spotlight: THP-1 Macrophage Response to LPS/ATP — Unveiling the Pyroptosis, Apoptosis, and Necroptosis Spectrum
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Author Spotlight: THP-1 Macrophage Response to LPS/ATP — Unveiling the Pyroptosis, Apoptosis, and Necroptosis Spectrum

Published on: May 3, 2024

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New perspective for pathomechanism and clinical applications of animal toxins: Programmed cell death

Jiaqi Sun1, Jiahao Liu2, Meiling Liu2

  • 1Queen Mary School, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, China.

Toxicon : Official Journal of the International Society on Toxinology
|August 12, 2024
PubMed

Insights

Animal toxins threaten human safety, making programmed cell death (PCD) research crucial. This review examines how toxins interact with PCD types like apoptosis and pyroptosis for better treatment strategies.

Area of Science:

  • Toxicology
  • Cell Biology
  • Pathophysiology

Background:

  • Animal toxins present significant health risks, requiring advanced research for effective treatments.
  • Programmed cell death (PCD) is a critical biological process implicated in various pathophysiological conditions, including envenomation.

Purpose of the Study:

  • To explore the intricate relationship between diverse animal toxins and distinct forms of programmed cell death (PCD).
  • To provide a comprehensive reference for understanding toxin-induced pathophysiology and identifying potential clinical applications.

Main Methods:

  • Literature review synthesizing current research on animal toxins and their mechanisms.
  • Analysis of the interplay between toxins and specific PCD pathways: apoptosis, necroptosis, autophagy, ferroptosis, and pyroptosis.

Main Results:

  • Identified specific toxin components contributing to pathomechanisms and cellular injury.
  • Detailed the involvement of various PCD types in response to different animal toxins.

Conclusions:

  • Understanding toxin-PCD interactions is vital for advancing envenomation treatment strategies.
  • This review offers a foundation for future research into the clinical potential of targeting PCD in toxicology.
Keywords:
Animal toxinsMelittinPathomechanismProgrammed cell deathSnake venom

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