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Related Experiment Video

Updated: Jun 17, 2025

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication

Published on: February 6, 2019

Adolescent Thalamoprefrontal Inhibition Leads to Changes in Intrinsic Prefrontal Network Connectivity.

David Petersen^1,2, Ricardo Raudales^1,2, Ariadna Kim Silva^1,2

¹Departments of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York 10032.

|August 12, 2024

Summary

Inhibiting thalamoprefrontal pathways during adolescence impairs adult prefrontal cortex function. This study reveals specific synaptic changes and highlights the importance of intraprefrontal connectivity for cognitive development.

Keywords:

adolescence excitation inhibition balance prefrontal cortex maturation thalamocortical projections

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Online Transcranial Magnetic Stimulation Protocol for Measuring Cortical Physiology Associated with Response Inhibition

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Published on: February 8, 2018

Area of Science:

Neuroscience
Developmental Neuroscience
Cognitive Neuroscience

Background:

Adolescent thalamocortical pathway activity is crucial for prefrontal cortex maturation.
The precise impact of inhibiting these projections during adolescence on prefrontal circuitry remains largely unknown.

Purpose of the Study:

To investigate how chemogenetic inhibition of thalamoprefrontal projections during a specific adolescent window (postnatal days 20-35) affects synaptic inputs in the adult mouse prefrontal cortex.
To determine the role of these changes in cognitive function.

Main Methods:

Chemogenetic inhibition of thalamoprefrontal projections in male/female mice (P20-35).
Slice physiology to measure excitatory and inhibitory synaptic currents in prefrontal pyramidal neurons (by layer and projection target).
Cognitive behavioral tests in adult mice.

Main Results:

Layer- and projection-specific alterations in excitatory and inhibitory synaptic current frequency and amplitude were observed.
The balance of excitation/inhibition was only disrupted in contralateral mPFC-projecting neurons, suggesting homeostatic regulation in subcortical projections.
Cognitive deficits were evident in adult mice subjected to this adolescent inhibition window.

Conclusions:

Adolescent thalamocortical inhibition induces complex, specific synaptic alterations in the prefrontal cortex.
Homeostatic regulation appears to differ between subcortical and intracortical projection neurons.
Targeted inhibition of intraprefrontal connectivity may be critical for normal prefrontal cortex maturation and cognitive function.