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Related Experiment Video

Updated: Jun 17, 2025

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A roadmap towards improving outcomes in multiple myeloma.

Mohamad Mohty1, Thierry Facon2, Florent Malard3

  • 1Sorbonne Université, Centre de Recherche Saint-Antoine INSERM UMRs938, Service d'Hématologie Clinique et de Thérapie Cellulaire, Hôpital Saint Antoine, AP-HP, Paris, France. mohamad.mohty@inserm.fr.

Blood Cancer Journal
|August 12, 2024
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Summary

Multiple myeloma (MM) remains incurable, with most patients relapsing. Improving outcomes requires addressing non-therapy issues like real-world data and drug accessibility, alongside new treatments.

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Area of Science:

  • Hematology
  • Oncology
  • Immunotherapy

Background:

  • Multiple myeloma (MM) is an incurable chronic hematologic malignancy with increasing global incidence.
  • Most MM patients experience disease relapse or become refractory to existing therapies.
  • Novel immunotherapies offer improved treatment options, but non-therapy factors are critical for better patient outcomes.

Purpose of the Study:

  • To discuss key non-therapy-related issues crucial for improving multiple myeloma outcomes.
  • To highlight the need for real-world evidence and better risk stratification in MM care.
  • To emphasize the importance of drug accessibility and diversity in clinical research for MM patients.

Main Methods:

  • This is a perspective review discussing critical issues in multiple myeloma management.
  • Key areas examined include real-world evidence, frailty assessment, and risk stratification.
  • The review also addresses novel drug accessibility and the need for diverse patient representation.

Main Results:

  • Current MM treatments, including novel immunotherapies, show promise but are insufficient alone.
  • Addressing non-therapy factors is a prerequisite for significantly improving MM patient outcomes.
  • Essential factors include real-world data, defined frailty, dynamic risk assessment, and equitable drug access.

Conclusions:

  • Improving multiple myeloma outcomes necessitates a multifaceted approach beyond novel therapies.
  • Key areas for advancement include real-world evidence, refined risk assessment, and broader access to innovative treatments.
  • Ensuring diversity in research and treatment is vital for advancing MM care for all patient groups.