Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Learning Temporal Relationships Between Symbols with Laplace Neural Manifolds.

Computational brain & behavior·2026

Same author

Translating lineage-resolved single-cell programs to bulk clinical prognosis: Adversarial generative learning reveals lineage-informed immune - stromal - epithelial risk signatures.

Computational biology and chemistry·2026

Same author

Population genomics and disease risk of primary cutaneous amyloidosis: A prominent genodermatosis of Southeast Asia.

Journal of the Formosan Medical Association = Taiwan yi zhi·2026

Same author

A validated prediction model for intestinal vancomycin-resistant Enterococcus colonization in critically ill patients with sepsis: insights into risk stratification and clinical impact.

BMC infectious diseases·2026

Same author

Induced Regulatory T Cells Attenuate Poly I:C-Triggered Acute Lung Injury by Modulating Cytokine Responses.

Journal of immunology research·2026

Same author

Ultrasound-assisted enzymatic extraction improves the antiinflammatory activity of red dragon fruit peel pectin.

Turkish journal of biology = Turk biyoloji dergisi·2026

Search research articles

Related Experiment Video

Updated: Jun 17, 2025

Author Spotlight: Exploring Sex-Specific Glial Signatures and Therapeutic Leads for Alzheimer's Disease

Author Spotlight: Exploring Sex-Specific Glial Signatures and Therapeutic Leads for Alzheimer's Disease

Published on: May 20, 2024

Multiple Transcriptomic Analyses Explore Potential Synaptic Biomarker Rabphilin-3A for Alzheimer's Disease.

Doan Phuong Quy Nguyen^1,2, Son Pham³, Amadou Wurry Jallow¹

¹Ph.D. Program in Medical Biotechnology, College of Medical Science and Technology, Taipei Medical University, No. 301, Yuantong Rd., Zhonghe Dist., New Taipei City, 235, Taiwan.

Scientific Reports

|August 12, 2024

Summary

Researchers identified 19 potential Alzheimer's disease (AD) gene candidates by analyzing blood and tissue transcriptomic data. One gene, RPH3A, showed reduced levels in AD model mice, suggesting its role in synaptic dysfunction.

Keywords:

Alzheimer’s disease Microarray Rabphilin-3A Synaptic signaling Transcriptome

More Related Videos

A High-content Assay for Monitoring AMPA Receptor Trafficking

A High-content Assay for Monitoring AMPA Receptor Trafficking

Published on: January 28, 2019

A High Throughput, Multiplexed and Targeted Proteomic CSF Assay to Quantify Neurodegenerative Biomarkers and Apolipoprotein E Isoforms Status

A High Throughput, Multiplexed and Targeted Proteomic CSF Assay to Quantify Neurodegenerative Biomarkers and Apolipoprotein E Isoforms Status

Published on: October 20, 2016

Related Experiment Videos

Last Updated: Jun 17, 2025

Author Spotlight: Exploring Sex-Specific Glial Signatures and Therapeutic Leads for Alzheimer's Disease

Author Spotlight: Exploring Sex-Specific Glial Signatures and Therapeutic Leads for Alzheimer's Disease

Published on: May 20, 2024

A High-content Assay for Monitoring AMPA Receptor Trafficking

A High-content Assay for Monitoring AMPA Receptor Trafficking

Published on: January 28, 2019

A High Throughput, Multiplexed and Targeted Proteomic CSF Assay to Quantify Neurodegenerative Biomarkers and Apolipoprotein E Isoforms Status

A High Throughput, Multiplexed and Targeted Proteomic CSF Assay to Quantify Neurodegenerative Biomarkers and Apolipoprotein E Isoforms Status

Published on: October 20, 2016

Area of Science:

Neuroscience
Genetics
Molecular Biology

Background:

Alzheimer's disease (AD) is a major neurodegenerative disorder affecting global elderly populations.
Identifying novel gene candidates is crucial for developing AD diagnostic biomarkers and therapeutic strategies.

Purpose of the Study:

To identify and validate novel gene candidates associated with Alzheimer's disease.
To explore the expression patterns and functional relevance of these candidate genes in AD pathology.

Main Methods:

Integrated transcriptomic data from microarray and single-cell sequencing of blood and brain tissue.
Performed gene expression analysis, functional enrichment, and validation in an AD mouse model.

Main Results:

Identified 19 candidate genes with consistent expression changes in both blood and tissue datasets.
Found specific expression of candidate genes in excitatory and inhibitory neurons.
Discovered downregulation of three candidate genes in the synaptic signaling pathway, with RPH3A validation in an AD mouse model.

Conclusions:

The identified genes, particularly RPH3A, represent promising biomarkers and potential therapeutic targets for Alzheimer's disease.
RPH3A's reduced levels and role in synaptic function highlight its significance in AD pathogenesis.
Further research into RPH3A and its interactions may elucidate mechanisms of synaptic dysfunction in AD.