Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 17, 2025

Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips
14:44

Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips

Published on: October 20, 2018

26.6K

Organs on chips: fundamentals, bioengineering and applications.

Nasser K Awad1

  • 1Physical Chemistry Department, Advanced Materials Technology and Mineral Resources Research Institute, National Research Centre, Dokki, 12422, Cairo, Egypt. awadnrc@gmail.com.

Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs
|August 12, 2024
PubMed
Summary

Organs on chips offer dynamic cell culture, overcoming limitations of traditional 2D/3D methods. These advanced systems mimic human organs, aiding drug validation and disease mechanism studies, including COVID-19 vaccine development.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same journal

Investigation of the cleaning effect by the intermittent backfiltration in diafilters with polysulfone and polymethylmethacrylate membranes.

Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs·2026
Same journal

Fracture of the cannula tip during removal of a long-term indwelling Impella 5.5: a case report.

Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs·2026
Same journal

Psychological and socioeconomic impact of long-term home management on patients with left ventricular assist devices and their caregivers: a nationwide multicenter questionnaire survey.

Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs·2026
Same journal

Assessment of aortic insufficiency during Impella support as a bridge to durable left ventricular assist device implantation and its long-term progression.

Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs·2026
Same journal

Development of a novel anticoagulant and fibrinolytic management monitoring method during extracorporeal circulation using clot-fibrinolysis waveform analysis: the effects of anticoagulants on coagulation and fibrinolysis functions.

Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs·2026
Same journal

Outcomes of donation after circulatory death heart transplant using normothermic regional perfusion: a systematic review and meta-analysis.

Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs·2026

Area of Science:

  • Biomedical Engineering
  • Cell Biology
  • Physiology

Background:

  • Traditional 2D and 3D cell cultures fail to replicate the human body's complex fluid mechanics and biomechanics.
  • Existing cell culture models lack the necessary spatiotemporal conditions for accurate cellular representation.
  • Current platforms do not adequately support the study of cell-cell interactions in multi-cellular environments.

Purpose of the Study:

  • To introduce the concept and fabrication of organs on chips (OoC) systems.
  • To highlight the advantages of dynamic cell culture systems over traditional methods.
  • To discuss the applications of OoC in drug validation and disease mechanism research.

Main Methods:

  • Fabrication of organs on chips systems to mimic specific organ functions.
Keywords:
BioengineeringMicrofluidicsOrgans on chipsRecapitulate

More Related Videos

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids
08:22

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids

Published on: August 11, 2017

15.7K
Generation of a Human iPSC-Based Blood-Brain Barrier Chip
10:20

Generation of a Human iPSC-Based Blood-Brain Barrier Chip

Published on: March 2, 2020

12.5K

Related Experiment Videos

Last Updated: Jun 17, 2025

Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips
14:44

Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips

Published on: October 20, 2018

26.6K
Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids
08:22

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids

Published on: August 11, 2017

15.7K
Generation of a Human iPSC-Based Blood-Brain Barrier Chip
10:20

Generation of a Human iPSC-Based Blood-Brain Barrier Chip

Published on: March 2, 2020

12.5K
  • Development of dynamic cell culture platforms.
  • Utilizing OoC for studying cell-cell interactions and physiological conditions.

    • Main Results:

    • Organs on chips systems successfully demonstrate the ability to mimic specific organ functions.
    • These systems provide a platform for studying dynamic cellular processes and interactions.
    • OoC technology has proven effective in validating drugs and understanding disease mechanisms.

    Conclusions:

    • Organs on chips represent a significant advancement in biological system modeling.
    • This technology overcomes limitations of traditional cell culture, offering better physiological relevance.
    • OoC systems are crucial for accelerating drug discovery, vaccine development (e.g., COVID-19), and understanding complex diseases.