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Related Experiment Videos

Human conglutinin-like protein.

J C Jensenius, S Thiel, G Baatrup

    Bioscience Reports
    |October 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Researchers found a human protein similar to bovine conglutinin in plasma. This conglutinin-like protein binds to complement-treated IgG in a calcium-dependent manner, suggesting a role in the human immune system.

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    Area of Science:

    • Immunology
    • Biochemistry

    Background:

    • Bovine conglutinin is a known immune protein.
    • The existence of a human homolog was previously unconfirmed.

    Purpose of the Study:

    • To investigate the presence and characteristics of a human conglutinin-like protein in plasma.
    • To determine the binding properties and molecular nature of this human protein.

    Main Methods:

    • Biological and immunochemical analyses were performed.
    • Calcium-dependent binding assays to complement-treated IgG were conducted.
    • SDS-PAGE and Western blotting were used for molecular characterization.

    Main Results:

    • A human plasma molecule homologous to bovine conglutinin was identified.

    Related Experiment Videos

  • This protein exhibited calcium-dependent binding to complement-treated IgG.
  • Binding was specifically inhibited by N-acetyl-D-glucosamine.
  • SDS-PAGE and Western blot analysis revealed similarities to bovine conglutinin monomers and hexamers.

    • Conclusions:

    • Human plasma contains a conglutinin-like protein with functional and structural similarities to bovine conglutinin.
    • This protein's specific sugar-binding properties suggest a role in innate immunity and pathogen recognition.