Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Higher Mental Functions of the Brain: Language

Higher Mental Functions of the Brain: Language

Language is a system of communication that allows the expression of thoughts, ideas, and feelings. The brain processes language in both hemispheres.
Language formation and comprehension take place in the dominant hemisphere. The dominant hemisphere is responsible for understanding the meaning of spoken, written, or sign language, as well as the ability to communicate. For most people, the left hemisphere is the dominant one. The right hemisphere, then, gives tone and emotional context to the...

Cerebral Hemispheres

Cerebral Hemispheres

The human brain, a complex organ, is functionally divided into two cerebral hemispheres—left and right. These hemispheres are interconnected by a structure of paramount importance, the corpus callosum. This substantial bundle of neural fibers is not just a bridge between the hemispheres but a crucial element for the brain's comprehensive functioning. It enables efficient communication between the two hemispheres, allowing each side of the brain to control and receive sensory and motor...

Lateralization

Lateralization

Brain lateralization refers to the division of mental processes and functions between the two hemispheres of the brain, a phenomenon that optimizes neural efficiency and underpins complex abilities in humans. This specialization allows each hemisphere to perform tasks where it has a comparative advantage, facilitating more refined cognitive capabilities across different domains.

Language and Cognition

Language and Cognition

Language serves as a bridge between ideas and communication, influencing how individuals perceive and interact with the world. Psychologists have long debated whether language shapes thought or vice versa. This discussion gained grip with Edward Sapir and Benjamin Lee Whorf in the 1940s, who proposed that language determines thought, a concept known as linguistic determinism. They suggested that the vocabulary and structure of a language influence how its speakers think and perceive reality.

Learning Disabilities

Learning Disabilities

Learning disabilities are cognitive disorders caused by neurological impairments that affect cognitive functions like language and reading, without indicating overall intellectual or developmental challenges. These disabilities differ from global intellectual or developmental disabilities as they are limited to distinct cognitive functions. Common learning disabilities include dysgraphia, dyslexia, and dyscalculia, each of which impacts unique aspects of learning.
Dyslexia
Dyslexia is a...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Rapid generation of human sensory neurons from iPSC for modeling of peripheral neuropathies.

Journal of neuroscience methods·2026

Same author

Prevalence and Characterization of Campylobacter Species Isolated from U.S. Swine: 2021 NAHMS Enteric Study.

Journal of food protection·2025

Same author

A national survey of the gastrointestinal nematode control practices used by goat producers in the United States.

Veterinary parasitology·2025

Same author

GCPII Inhibition Promotes Remyelination after Peripheral Nerve Injury in Aged Mice.

International journal of molecular sciences·2024

Same author

Prevalence, Antimicrobial Resistance, and Diversity of <i>Campylobacter</i> Isolated from U.S. Goat Feces: 2019 NAHMS Survey.

Foodborne pathogens and disease·2024

Same author

Tumor necrosis factor α receptor 1A transduces the inhibitory effect on axon regeneration triggered by IgG anti-ganglioside GD1a antibodies.

Biochimica et biophysica acta. Molecular basis of disease·2024

Search research articles

Related Experiment Video

Updated: Jun 17, 2026

Assessing Neural Stem Cell Motility Using an Agarose Gel-based Microfluidic Device

Assessing Neural Stem Cell Motility Using an Agarose Gel-based Microfluidic Device

Published on: February 11, 2008

Live Imaging Analysis of Axonal Regeneration in Human iPSC-Derived Motor Neurons Using a Microfluidic System.

Katherine L Marshall¹, Mohamed H Farah²

¹Department of Neurology, Neuromuscular Division, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Methods in Molecular Biology (Clifton, N.J.)

|August 12, 2024

Summary

Researchers developed a new method to study human axonal regeneration using specialized microfluidic systems. This breakthrough allows for live imaging of human-induced pluripotent stem cell-derived neurons, aiding in the development of treatments for nervous system repair.

Keywords:

Axonal regeneration Axotomy Human iPSCs Live imaging Microfluidic devices Motor neurons Neuronal cytoskeletal markers Outgrowth

More Related Videos

Axonal Transport of Organelles in Motor Neuron Cultures using Microfluidic Chambers System

Axonal Transport of Organelles in Motor Neuron Cultures using Microfluidic Chambers System

Published on: May 5, 2020

Generation of Human Motor Units with Functional Neuromuscular Junctions in Microfluidic Devices

Generation of Human Motor Units with Functional Neuromuscular Junctions in Microfluidic Devices

Published on: September 7, 2021

Related Experiment Videos

Last Updated: Jun 17, 2026

Assessing Neural Stem Cell Motility Using an Agarose Gel-based Microfluidic Device

Assessing Neural Stem Cell Motility Using an Agarose Gel-based Microfluidic Device

Published on: February 11, 2008

Axonal Transport of Organelles in Motor Neuron Cultures using Microfluidic Chambers System

Axonal Transport of Organelles in Motor Neuron Cultures using Microfluidic Chambers System

Published on: May 5, 2020

Generation of Human Motor Units with Functional Neuromuscular Junctions in Microfluidic Devices

Generation of Human Motor Units with Functional Neuromuscular Junctions in Microfluidic Devices

Published on: September 7, 2021

Area of Science:

Neuroscience
Stem Cell Biology
Regenerative Medicine

Background:

Axonal damage is prevalent in traumatic injuries and neurodegenerative diseases.
While peripheral nerves show regeneration, human axonal regeneration is limited, hindering functional recovery.
Current methods for studying human axonal regeneration are insufficient.

Purpose of the Study:

To establish a novel system for evaluating human axonal outgrowth and regeneration dynamics.
To enable live imaging of human-induced pluripotent stem cell (hiPSC)-derived neurons in a controlled microenvironment.
To provide a platform for testing therapeutic compounds for nervous system repair.

Main Methods:

Utilized microfluidic devices to culture hiPSC-derived neurons with isolated cell bodies and axons.
Employed live imaging techniques to observe axonal dynamics in real-time.
Developed a system that mimics in vivo conditions for axonal growth studies.

Main Results:

Successfully demonstrated the ability to culture and image hiPSC-derived neurons in microfluidic systems.
Observed and quantified human axonal outgrowth and regeneration dynamics.
Validated the system's utility for studying neuronal repair mechanisms.

Conclusions:

The developed microfluidic system offers a powerful tool for studying human axonal regeneration.
This platform facilitates research into the mechanisms underlying neuronal repair.
It holds potential for accelerating the discovery of drugs promoting nervous system recovery.