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Lipid accumulation product and type 2 diabetes risk: a population-based study
Sepehr Sadafi1,2, Ali Azizi3,4, Farid Najafi5
1Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.
BMC Endocrine Disorders
|August 12, 2024
Summary
Elevated Lipid Accumulation Product (LAP) levels are strongly associated with type 2 diabetes mellitus (T2DM) in adults from western Iran. This finding suggests LAP may serve as a valuable screening tool for diabetes risk.
Area of Science:
- Metabolic Health
- Epidemiology
- Diabetes Research
Background:
- Lipid Accumulation Product (LAP) quantifies excessive body fat and is studied for its role in predicting chronic and metabolic diseases.
- Previous research highlights LAP's significance in epidemiological studies for forecasting disease risk.
Purpose of the Study:
- To investigate the association between Lipid Accumulation Product (LAP) and type 2 diabetes mellitus (T2DM).
- To evaluate the predictive capability of LAP for T2DM in an adult population in western Iran.
Main Methods:
- Analysis of data from 9,065 adults in the Ravansar non-communicable diseases (RaNCD) cohort study.
- Utilized multiple logistic regression to assess the LAP-T2DM association.
- Employed Receiver Operating Characteristic (ROC) curve analysis to determine LAP's predictive accuracy for T2DM.
Main Results:
- Participants averaged 47.24 ± 8.27 years, with near-equal gender distribution (49.30% male, 50.70% female).
- Mean LAP was significantly higher in the diabetic group (75.51 ± 51.34) compared to the healthy group (53.10 ± 36.60) (P < 0.001).
- Logistic regression showed increased odds of T2DM with higher LAP quartiles, with the highest quartile exhibiting 3.73 times greater odds (95% CI: 2.83, 4.92). ROC analysis yielded an AUC of 0.66 (95% CI: 0.64, 0.68) for T2DM prediction.
Conclusions:
- A significant association exists between elevated LAP levels and T2DM in western Iranian adults.
- LAP is a promising indicator for screening individuals susceptible to developing diabetes.
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