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Related Concept Videos

Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

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Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
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Role of Skin in Vitamin D Synthesis01:23

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The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
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  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Association Between Serum Vitamin D Status And Severity Of Liver Cirrhosis: Implications For Therapeutic Targeting In Nigerian Patients.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Association Between Serum Vitamin D Status And Severity Of Liver Cirrhosis: Implications For Therapeutic Targeting In Nigerian Patients.

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Association between serum vitamin D status and severity of liver cirrhosis: implications for therapeutic targeting in Nigerian patients.

Winnifred Njideka Adiri1, Bruno Basil2, Chinwe Philomena Onyia1

  • 1Gastroenterology Unit, Department of Medicine, University of Nigeria Teaching Hospital, Ituku-Ozalla, Nigeria.

BMC Gastroenterology
|August 12, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Low vitamin D levels are linked to more severe liver cirrhosis in Nigerian patients. This suggests vitamin D may be a useful marker and potential treatment target for this chronic liver disease.

Keywords:
Liver cirrhosisNigerianSeverityTherapeutic targeting

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Area of Science:

  • Hepatology
  • Endocrinology
  • Nutritional Science

Background:

  • Liver cirrhosis is a significant global health concern.
  • Emerging evidence links serum vitamin D levels to cirrhosis severity, indicating potential therapeutic value.

Purpose of the Study:

  • To investigate the association between serum vitamin D status and liver cirrhosis severity in Nigerian patients.

Main Methods:

  • A cross-sectional study of 201 participants (103 with cirrhosis, 98 controls).
  • Serum vitamin D measured by ELISA; deficiency defined as <20 ng/ml.
  • Cirrhosis severity assessed using Child-Pugh and MELD scores; Spearman correlation and ordinal regression used.

Main Results:

  • 36.9% of cirrhotic patients had vitamin D deficiency.
Vitamin D
  • Serum vitamin D negatively correlated with Child-Pugh (r=-0.696) and MELD scores (r=-0.734).
  • Higher vitamin D levels were associated with lower cirrhosis severity scores (Child-Pugh OR=0.856, MELD OR=0.875).

    • Conclusions:

    • Lower serum vitamin D levels correlate with increased liver cirrhosis severity.
    • Vitamin D may serve as a prognostic marker and therapeutic target for liver cirrhosis.
    • Further research is needed on vitamin D supplementation's efficacy in improving cirrhosis outcomes.