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The YTH domain-containing protein family: Emerging players in immunomodulation and tumour immunotherapy targets

Fenghe Li1, Chong Zeng2, Jie Liu3

  • 1Department of Gynaecology and Obstetrics, Second Xiangya Hospital, Central South University, Changsha, China.

Clinical and Translational Medicine
|August 13, 2024
PubMed
Abstract

Insights

The YTH domain protein family regulates immune responses and antitumor immunity through N6-methyladenosine (m6A) modifications. Understanding their roles is crucial for advancing cancer immunotherapy and overcoming tumor resistance.

Area of Science:

  • Molecular Biology
  • Immunology
  • Oncology

Background:

  • N6-methyladenosine (m6A) modification impacts tumor immunity by regulating messenger RNA.
  • YTH domain proteins, as m6A
  • readers
  • influence RNA processing and immunogenicity, impacting immune regulation and antitumor responses.

Purpose of the Study:

  • To comprehensively review the molecular characteristics and roles of the YTH domain protein family.
  • To elucidate their mechanisms in immune regulation and antitumor immunity.
  • To explore their involvement in immune-related diseases and tumor resistance.

Main Methods:

  • Literature review of studies on YTH domain proteins and m6A modification.
  • Analysis of YTH protein functions in physiological and pathological contexts.
  • Synthesis of current knowledge on YTH proteins in tumor immunity and therapy.

Main Results:

  • YTH domain proteins are key regulators of RNA splicing, stability, and immunogenicity.
  • Their functions are critical for both innate and adaptive immune responses in tumors.
  • Dysregulation of YTH proteins is associated with tumor initiation, progression, and therapeutic resistance.

Conclusions:

  • The YTH domain protein family plays a significant role in antitumor immunity and immune regulation.
  • Understanding YTH protein mechanisms offers potential for novel immunotherapy strategies.
  • Targeting YTH proteins may help overcome tumor resistance and improve treatment outcomes.
Keywords:
YTH domain‐containing protein familyanti‐tumour immunityimmunoregulationm6A methylation

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